Liu Wen-dong, Wu Ying, Liang Qi, Hu Jian-li, Dai Qi-gang, Li Yuan, Ai Jing, Tang Fen-yang
Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2012 Aug;33(8):813-7.
To analyze the epidemic characteristics of hand-foot-mouth disease (HFMD) in Jiangsu province.
We downloaded the case-data of HFMD in Jiangsu province during 2009 - 2011 from the Chinese National Notifiable Infectious Disease Reporting System, and made a comprehensive analysis on the epidemiological features of it with descriptive epidemiological methods and retrospective space-time permutation scan statistics.
A total of 285 414 cases were reported in Jiangsu, from 2009 to 2011, with an annual incidence of 122.66 per 100 000. There were 3686 severe cases in the 3 years a cumulatively, accounting for 1.29% of the total. Proportion of the cases being 5 years old or even younger was 93.64%. Scatteredly living children accounted for 64.08% of the total cases and 78.65% of the severe cases, respectively. The epidemics of HFMD were visible in each city of Jiangsu province, with a lowest annual incidence rate of 44.02 per 100 000 and a highest one up to 202.90 per 100 000. Regions as Suzhou, Nanjing, Wuxi had the highest incidence in the province, with cases in these three areas occupying almost 40% of all. The numbers of severe cases in Suqian and in Yancheng cities increased by 339.22% and 328.33% in 2011 compared to in 2010, respectively, and the rates of increase in these two cities were much higher than those in the other regions. Two peaks of incidence were observed every year, with the highest occurring between April and June and the second occurring in November. The spatial-temporal distribution of HFMD was not random in Jiangsu province, from 2009 to 2011. Clusters for general cases in August and 7 clusters for severe cases were detected, respectively. 12 359 cases of HFMD were laboratory confirmed in the said 3 years, including 10 414 common cases and 1945 severe cases. EV71 and CoxA16 accounted for 43.49% and 37.07% of common cases, respectively. In terms of the severe cases, the ratios were 80.82% and 5.96%, respectively.
HFMD was highly endemic in Jiangsu province, and the situation of prevention and control for it is still grim. Scatteredly living children of 5 years old or younger were the major population at risk, and the epidemic in different regions and seasons was different. EV71 and CoxA16 were the major etiologic agents, but the etiologic constitute showed seasonal changes.
分析江苏省手足口病（HFMD）的流行特征。
从中国国家法定传染病报告系统下载2009 - 2011年江苏省手足口病病例数据，采用描述性流行病学方法和回顾性时空排列扫描统计对其流行病学特征进行综合分析。
2009 - 2011年江苏省共报告285414例手足口病病例，年发病率为十万分之122.66。3年累计重症病例3686例，占总病例数的1.29%。5岁及以下病例占93.64%。散居儿童分别占总病例数的64.08%和重症病例数的78.65%。江苏省各市均有手足口病疫情，年发病率最低为十万分之44.02，最高达十万分之202.90。苏州、南京、无锡发病率居全省最高，这三个地区的病例数占全省近40%。2011年宿迁市和盐城市重症病例数分别比2010年增加339.22%和328.33%，这两个城市的增长率远高于其他地区。每年出现两个发病高峰，最高峰值出现在4 - 6月，第二个峰值出现在11月。2009 - 2011年江苏省手足口病的时空分布并非随机。分别检测到8个普通病例聚集区和7个重症病例聚集区。3年中12359例手足口病病例经实验室确诊，其中普通病例10414例，重症病例1945例。肠道病毒71型（EV71）和柯萨奇病毒A16型（CoxA16）分别占普通病例的43.49%和37.07%。重症病例中，这两个比例分别为80.82%和5.96%。
手足口病在江苏省高度流行，防控形势依然严峻。5岁及以下散居儿童是主要高危人群，不同地区和季节疫情不同。EV71和CoxA16是主要病原体，但病原体构成呈现季节性变化。
