Department of Biochemistry and Molecular Biology, The George Washington University School of Medicine and Health Sciences, 2300 Eye St., NW, Washington, DC 20037, USA.
Neurotoxicology. 2012 Dec;33(6):1434-1435. doi: 10.1016/j.neuro.2012.07.009. Epub 2012 Aug 8.
It is becoming increasingly clear that gene-environment interactions are risk factors for autism. However, there is limited information regarding the susceptibility of specific autism candidate genes to dysregulation by environmental factors, and even less information on the types of environmental agents that may lead to increased risk for autism. Based on our published studies, I propose that the demonstrated responsiveness of RORA to sex hormones makes it a prime target for disruption by endocrine disrupting compounds.
越来越明显的是，基因-环境相互作用是自闭症的风险因素。然而，关于特定自闭症候选基因对环境因素失调的易感性的信息有限，关于可能导致自闭症风险增加的环境因素类型的信息就更少了。基于我们已发表的研究，我提出，RORA 对性激素的反应性表明它是内分泌干扰化合物破坏的主要目标。
