Department of Women's and Children's Health, Division of Obstetrics and Gynecology, Karolinska Institutet/University Hospital, Stockholm, Sweden.
Gynecol Endocrinol. 2013 Jan;29(1):59-62. doi: 10.3109/09513590.2012.705385. Epub 2012 Sep 11.
Several studies have suggested gender differences in cognitive function, but data on the association between sex hormones and cognitive function are contradictory. The aim of our randomized double-blind study was to explore the possible relations between cognitive function and serum levels of sex hormones, oxytocin and insulin-like growth factor-I (IGF-I) in postmenopausal women. Two-hundred healthy postmenopausal women were randomly assigned to receive estrogen, testosterone or placebo treatment for 1 month. The associations of spatial ability, verbal fluency and verbal memory with serum levels of estradiol, testosterone, estradiol/testosterone ratio, androstanediol, oxytocin and IGF-I were analyzed. Spatial ability showed a negative correlation with serum estradiol, estradiol/testosterone ratio, oxytocin levels and a positive association with androstanediol levels. Verbal fluency displayed a negative relationship with serum levels of testosterone, IGF-I and a positive with estradiol/testosterone ratio. Verbal memory displayed a positive correlation to androstanediol. Data suggest that not only absolute levels of sex hormones but also the balance between estrogen and testosterone and their metabolites may be important for cognitive function in women.
几项研究表明认知功能存在性别差异，但关于性激素与认知功能之间关系的数据存在矛盾。我们的随机双盲研究旨在探讨绝经后妇女的认知功能与血清性激素、催产素和胰岛素样生长因子-I（IGF-I）水平之间可能存在的关系。将 200 名健康绝经后妇女随机分配接受雌激素、睾酮或安慰剂治疗 1 个月。分析了空间能力、言语流畅性和言语记忆与雌二醇、睾酮、雌二醇/睾酮比、雄烷二醇、催产素和 IGF-I 血清水平的关系。空间能力与血清雌二醇、雌二醇/睾酮比、催产素水平呈负相关，与雄烷二醇水平呈正相关。言语流畅性与血清睾酮、IGF-I 水平呈负相关，与雌二醇/睾酮比呈正相关。言语记忆与雄烷二醇呈正相关。数据表明，不仅性激素的绝对水平，而且雌激素和睾酮及其代谢物之间的平衡，可能对女性的认知功能很重要。
