癌症中的 DNA 甲基化抑制剂：近期和未来的方法。
DNA methylation inhibitors in cancer: recent and future approaches.
机构信息
USR CNRS-Pierre Fabre n° 3388-ETaC Epigenetic Targeting of Cancer, CRDPF 3 avenue Hubert Curien, 31035 Toulouse Cedex 01, France.
出版信息
Biochimie. 2012 Nov;94(11):2280-96. doi: 10.1016/j.biochi.2012.07.025. Epub 2012 Aug 11.
This review presents the different human DNA methyltransferases (DNMTs), their biological roles, their mechanisms of action and their role in cancer. The description of assays for detecting DNMT inhibitors (DNMTi) follows. The different known DNMTi are reported along with their advantages, drawbacks and clinical trials. A discussion on the features of the future DNMT inhibitors will conclude this review.
这篇综述介绍了不同的人类 DNA 甲基转移酶（DNMTs）、它们的生物学作用、作用机制以及它们在癌症中的作用。接下来介绍了用于检测 DNMT 抑制剂（DNMTi）的不同检测方法。报告了不同已知的 DNMTi 及其优点、缺点和临床试验。最后，讨论了未来 DNMT 抑制剂的特点。
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