Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, PR China.
Gene. 2012 Oct 15;508(1):121-4. doi: 10.1016/j.gene.2012.07.065.
Recurrent graft infection limited the effect of LT, early recognition and prophylaxis of HBV recurrence are very important, and interleukin 28B (IL‐28B) gene was reported to be associated with HBV infection.
To explore the association between IL-28B single-nucleotide polymorphisms (SNPs) and graft re-infection after liver transplantation(LT).
21 recipients with hepatitis B virus(HBV) recurrence and 157 recipients without HBV recurrence were included. We studied three SNPs in the promoter region of IL-28B gene at the positions rs12979860,rs12980275 and rs8099917 by HRM analysis (high-resolution melting curve analysis).
Hepatic allograft dysfunction was more likely to be associated with IL-28B SNPs. However, there was no significant difference in the frequencies of IL-28B gene distribution in recipients with or without HBV recurrence.
IL-28B gene polymorphism may be associated with the prognosis of LT recipients but it needs more experiments.
复发性移植物感染限制了 LT 的效果，早期识别和预防 HBV 复发非常重要，白细胞介素 28B（IL-28B）基因已被报道与 HBV 感染有关。
探讨 IL-28B 单核苷酸多态性（SNP）与肝移植（LT）后移植物再感染的关系。
纳入 21 例 HBV 复发患者和 157 例无 HBV 复发患者。我们通过 HRM 分析（高分辨率熔解曲线分析）研究了 IL-28B 基因启动子区三个 SNP（rs12979860、rs12980275 和 rs8099917）。
肝移植受者肝功能障碍更可能与 IL-28B SNP 相关。然而，HBV 复发组和非复发组 IL-28B 基因分布频率无显著差异。
IL-28B 基因多态性可能与 LT 受者的预后有关，但需要更多的实验验证。
