Beyer Tobias A, Narimatsu Masahiro, Weiss Alexander, David Laurent, Wrana Jeffrey L
Center for Systems Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada.
Biochim Biophys Acta. 2013 Feb;1830(2):2268-79. doi: 10.1016/j.bbagen.2012.08.025. Epub 2012 Sep 5.
Members of the Transforming Growth Factor-beta (TGFβ) superfamily of cytokines are essential for early embryonic development and play crucial roles in pluripotency and differentiation of embryonic stem cells in vitro.
In this review, we discuss how TGFβ family signals are read by cells and how they are modulated by the cellular context. Furthermore, we review recent advances in our understanding of TGFβ function in embryonic stem cells and point out hot topics at the intersection of TGFβ signaling and stem cell biology fields.
TGFβ family signals are essential for early mammalian development and the importance of this pathway is reflected in pluripotent stem cells derived from the mammalian embryo.
Understanding signaling pathways underlying pluripotency and cell fate specification holds promises for the advent of personalized regenerative medicine. This article is part of a Special Issue entitled Biochemistry of Stem Cells.
转化生长因子-β（TGFβ）细胞因子超家族的成员对于早期胚胎发育至关重要，并且在体外胚胎干细胞的多能性和分化中发挥关键作用。
在本综述中，我们讨论细胞如何解读TGFβ家族信号以及它们如何受到细胞环境的调节。此外，我们回顾了我们对TGFβ在胚胎干细胞中功能理解的最新进展，并指出TGFβ信号传导与干细胞生物学领域交叉的热点话题。
TGFβ家族信号对于早期哺乳动物发育至关重要，并且该途径的重要性体现在源自哺乳动物胚胎的多能干细胞中。
了解多能性和细胞命运特化背后的信号通路有望推动个性化再生医学的出现。本文是名为“干细胞生物化学”的特刊的一部分。
