通过计算建模研究 YAP/TAZ 信号在细胞机械转导中的作用。

MERLN Institute for Technology-Inspired Regenerative Medicine, Department of Cell Biology-Inspired Tissue Engineering, Maastricht University, Maastricht, The Netherlands.

Department of Mechanical and Aerospace Engineering, University of California San Diego, La Jolla, CA, 92093-0411, USA.

NPJ Syst Biol Appl. 2024 Aug 15;10(1):90. doi: 10.1038/s41540-024-00414-9.

YAP/TAZ signaling pathway is regulated by a multiplicity of feedback loops, crosstalk with other pathways, and both mechanical and biochemical stimuli. Computational modeling serves as a powerful tool to unravel how these different factors can regulate YAP/TAZ, emphasizing biophysical modeling as an indispensable tool for deciphering mechanotransduction and its regulation of cell fate. We provide a critical review of the current state-of-the-art of computational models focused on YAP/TAZ signaling.

YAP/TAZ 信号通路受到多种反馈回路、与其他通路的串扰以及机械和生化刺激的调节。计算建模是揭示这些不同因素如何调节 YAP/TAZ 的有力工具，强调生物物理建模是破译机械转导及其对细胞命运的调节的不可或缺的工具。我们对目前专注于 YAP/TAZ 信号的计算模型的最新进展进行了批判性回顾。