Li Dong-Liang, Gao Yan-Jie, Yu Ming-Run, Yang Xue-Ying, Li Shu-Ming, Xu Jie, Liu Ying-Jie, Jiang Shu-Lin, Zhang Zheng, Xiao Dong, Yan Li, Jiang Gui-Yan, Wang Hong-Ping, Zhou Zhen-Hai, Ruan Yu-Hua, Shao Yi-Ming, Luo Feng-Ji
Chaoyang Center for Disease Control and Prevention, Beijing 100021, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2012 Jul;33(7):663-6.
To investigate the dynamic change and associated risk factors of HIV sero-conversion rate in Beijing.
809 sero-negative men who have sex with men (MSM) were recruited in the cohort from August to December in 2009. HIV sero-antibody, medicinal examination and behavior questionnaire interview were carried out every six months.
962 MSM with overall baseline prevalence of HIV infection as 6.34% (61/962) together with 809 sero-negative MSM, were enrolled in the cohort. Of the 809 sero-negative participants, 95.1% (769/ 809), 85.5% (692/809) and 71.0% (574/809) of them were retained in the 6-month, 12-month and 18-month follow-up visits, with 19, 29 and 17 of them became HIV sero-conversion at 6-month, 12-month, and 18-month follow-up visits and the HIV incidence rates appeared to be 5.47, 12.37 and 6.86 per 100 person-years respectively. The HIV incidence was 7.59 per 100 person-years in the 18 months follow-up visit. Factors including: younger than 25-years old (HR = 2.32, 95%CI: 1.39 - 3.87), having more than 8 MSM partners (HR = 2.50, 95%CI: 1.49 - 4.20), less than 2000¥ every month income (HR = 1.76, 95%CI: 1.05 - 2.95), having more than 4 homosexual partners in the last six months (HR = 3.50, 95%CI: 2.11 - 5.81), showing phimosis and redundant prepuce (HR = 2.47, 95%CI: 1.50 - 4.07) as well as positive syphilis test (HR = 2.62, 95%CI: 1.53 - 4.49) etc., were significantly associated with HIV incidence.
High HIV incidence was shown among MSM in Beijing and had spread fast in this population, calling for more favorable prevention measures to be taken.
调查北京地区HIV血清转化率的动态变化及相关危险因素。
2009年8月至12月，在该队列中招募了809名血清学阴性的男男性行为者（MSM）。每6个月进行一次HIV血清抗体检测、体格检查和行为问卷调查。
该队列共纳入962名MSM，HIV感染总体基线患病率为6.34%（61/962），其中809名血清学阴性MSM。在809名血清学阴性参与者中，95.1%（769/809）、85.5%（692/809）和71.0%（574/809）的参与者分别在6个月、12个月和18个月随访时仍在队列中，其中分别有19名、29名和17名参与者在6个月、12个月和18个月随访时发生HIV血清转化，HIV发病率分别为每100人年5.47、12.37和6.86例。18个月随访时HIV发病率为每100人年7.59例。包括：年龄小于25岁（HR = 2.32，95%CI：1.39 - 3.87）、有超过8名MSM性伴（HR = 2.50，95%CI：1.49 - 4.20）、月收入低于2000元（HR = 1.76，95%CI：1.05 - 2.95）、过去6个月内有超过4名同性性伴（HR = 3.50，95%CI：2.11 - 5.81）、存在包茎和包皮过长（HR = 2.47，95%CI：1.50 - 4.07）以及梅毒检测阳性（HR = 2.62，95%CI：1.53 - 4.49）等因素与HIV发病率显著相关。
北京地区MSM人群HIV发病率较高且传播迅速，需采取更有效的预防措施。
