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血管内治疗在外周动脉病变中的应用:对2007年至2009年国家创伤数据库的分析

Use of endovascular therapy for peripheral arterial lesions: an analysis of the National Trauma Data Bank from 2007 to 2009.

作者信息

Worni Mathias, Scarborough John E, Gandhi Mihir, Pietrobon Ricardo, Shortell Cynthia K

机构信息

Research on Research Group, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.

出版信息

Ann Vasc Surg. 2013 Apr;27(3):299-305. doi: 10.1016/j.avsg.2012.04.007. Epub 2012 Sep 9.

DOI:10.1016/j.avsg.2012.04.007
PMID:22968090
Abstract

BACKGROUND

An endovascular approach is increasingly used for the treatment of peripheral arterial trauma (PAT), but evidence supporting this approach is lacking. The objective of our study was to assess outcomes for endovascular repair (ER) versus operative repair (OR) in PAT.

METHODS

We used the National Trauma Data Bank from 2007 to 2009 for our analysis, comparing in-hospital morbidity and mortality for all adult patients undergoing ER versus OR for PAT of the upper and lower extremities. Unadjusted and risk-adjusted generalized linear models were performed, with multiple imputation techniques being used to replace missing values.

RESULTS

Of 8,977 patients, 531 (5.9%) underwent ER. Most patients were male (77.1%) and Caucasian (42.6%), with a mean age of 34.7 years (standard deviation: 14.8). ER was performed more commonly for lower- (n = 370, 10.4%) than upper-extremity lesions (n = 161, 3.0%, P < 0.001). Risk-adjusted analysis showed that ER patients had significantly greater injury severity scores (P < 0.001), were more likely to suffer a blunt (vs. penetrating) mechanism of injury (P < 0.001), and were more likely to have multiple comorbid illnesses (P < 0.001) than OR patients. Overall, risk-adjusted complications were less frequent after ER than OR (risk-adjusted OR: 0.79, P = 0.05), whereas in-hospital mortality between the two groups did not differ (risk-adjusted OR: 1.10, P = 0.59). Length of hospital stay was shorter among ER patients (adjusted mean difference: 0.78 days, P < 0.001), whereas length of intensive care unit stay did not differ between the two groups (P = 0.44).

CONCLUSIONS

ER appears to be a viable option for patients with PAT. Further research is needed to identify potential subgroups of PAT patients in whom ER may be superior to OR.

摘要

背景

血管内治疗方法越来越多地用于治疗外周动脉创伤(PAT),但支持这种方法的证据仍然不足。我们研究的目的是评估PAT患者血管内修复(ER)与手术修复(OR)的疗效。

方法

我们使用2007年至2009年的国家创伤数据库进行分析,比较所有接受上肢和下肢PAT的ER与OR治疗的成年患者的院内发病率和死亡率。采用未调整和风险调整的广义线性模型,并使用多重填补技术来替代缺失值。

结果

在8977例患者中,531例(5.9%)接受了ER治疗。大多数患者为男性(77.1%)和白种人(42.6%),平均年龄为34.7岁(标准差:14.8)。ER治疗下肢病变(n = 370,10.4%)比上肢病变(n = 161,3.0%)更常见(P < 0.001)。风险调整分析显示,与OR患者相比,ER患者的损伤严重程度评分显著更高(P < 0.001),更有可能遭受钝性(与穿透性)损伤机制(P < 0.001),并且更有可能患有多种合并症(P < 0.001)。总体而言,ER后风险调整并发症比OR少(风险调整OR:0.79,P = 0.05),而两组间院内死亡率无差异(风险调整OR:1.10,P = 0.59)。ER患者的住院时间较短(调整后平均差异:0.78天,P < 0.001),而两组间重症监护病房住院时间无差异(P = 0.44)。

结论

ER似乎是PAT患者的一种可行选择。需要进一步研究以确定ER可能优于OR的PAT患者潜在亚组。

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