Cohen M B, Fisher P E, Holly E A, Ljung B M, Löwhagen T, Bottles K
Department of Pathology, College of Physicians and Surgeons Columbia University, New York, New York.
Acta Cytol. 1990 Jan-Feb;34(1):43-9.
Fine needle aspiration (FNA) biopsy is an increasingly popular method for the evaluation of salivary gland tumors. Of the common salivary gland tumors, mucoepidermoid carcinoma is probably the most difficult to diagnose accurately by this means. A series of 96 FNA biopsy specimens of salivary gland masses, including 34 mucoepidermoid carcinomas, 51 other benign and malignant neoplasms, 7 nonneoplastic lesions and 4 normal salivary glands, were analyzed in order to identify the most useful criteria for diagnosing mucoepidermoid carcinoma. Thirteen cytologic criteria were evaluated in the FNA specimens, and a stepwise logistic regression analysis was performed. The three cytologic features selected as most predictive of mucoepidermoid carcinoma were intermediate cells, squamous cells and overlapping epithelial groups. Using these three features together, the sensitivity and specificity of accurately diagnosing mucoepidermoid carcinoma were 97% and 100%, respectively.
细针穿刺（FNA）活检是评估唾液腺肿瘤越来越常用的方法。在常见的唾液腺肿瘤中，黏液表皮样癌可能是最难通过这种方法准确诊断的。分析了一系列96例唾液腺肿块的FNA活检标本，包括34例黏液表皮样癌、51例其他良恶性肿瘤、7例非肿瘤性病变和4例正常唾液腺，以确定诊断黏液表皮样癌最有用的标准。在FNA标本中评估了13项细胞学标准，并进行了逐步逻辑回归分析。被选为最能预测黏液表皮样癌的三个细胞学特征是中间细胞、鳞状细胞和重叠上皮细胞团。综合使用这三个特征，准确诊断黏液表皮样癌的敏感性和特异性分别为97%和100%。
