Cancer Research UK School of Cancer Sciences, University of Birmingham, Vincent Drive, Edgbaston, Birmingham B15 2TT, UK.
Br J Cancer. 2012 Oct 23;107(9):1595-601. doi: 10.1038/bjc.2012.405. Epub 2012 Sep 11.
There is a need for sensitive and specific blood-borne markers for the detection of gastric cancer. Raised serum macrophage inhibitory factor (MIF) levels have been proposed as a marker for gastric cancer diagnosis but, to date, studies have only encompassed patients from high-incidence areas.
We have compared the serum concentration of MIF in a large cohort of UK and Japanese gastric cancer patients, together with appropriate control subjects (age and gender matched). Carcinoembryonic antigen and H. pylori IgG were also measured, as was DJ-1, a novel candidate protein biomarker identified by analysis of gastric cancer cell line secretomes.
Marked elevations of the serum concentration of MIF and DJ-1 were seen in Japanese patients with gastric cancer compared with Japanese controls, a trend not seen in the UK cohort. These results could not be accounted for by differences in age, disease stage or H. pylori status.
In regions of high, but not low incidence of gastric cancer, both MIF and DJ-1 have elevated serum concentrations in gastric cancer patients, compared with controls. This suggests that differing mechanisms of disease pathogenesis may be at play in high- and low-incidence regions.
需要灵敏和特异的血液生物标志物来检测胃癌。血清巨噬细胞抑制因子（MIF）水平升高已被提议作为胃癌诊断的标志物，但迄今为止，这些研究仅涵盖了高发地区的患者。
我们比较了英国和日本大量胃癌患者及相应对照者（年龄和性别匹配）的血清 MIF 浓度。还检测了癌胚抗原和 H. pylori IgG，以及通过分析胃癌细胞系分泌组鉴定的新型候选蛋白生物标志物 DJ-1。
与日本对照组相比，日本胃癌患者的血清 MIF 和 DJ-1 浓度明显升高，而在英国队列中未观察到这种趋势。这些结果不能用年龄、疾病分期或 H. pylori 状态的差异来解释。
在胃癌高发地区，但不是低发地区，与对照组相比，胃癌患者的血清 MIF 和 DJ-1 浓度均升高。这表明在高发和低发地区，疾病发病机制的不同机制可能在起作用。
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