Department of Preventive and Social Dentistry, School of Dentistry, Seoul National University, Seoul, Korea.
J Korean Med Sci. 2012 Sep;27(9):1098-104. doi: 10.3346/jkms.2012.27.9.1098. Epub 2012 Aug 22.
Dental sealants and composite filling materials containing bisphenol-A (BPA) derivatives are increasingly used in children. The aim of this study was to evaluate the association between salivary BPA and the number of tooth surfaces filled with dental sealant, and to determine a cutoff BPA level. Salivary BPA concentration and the number of tooth surfaces filled with dental sealant/resin were determined in 124 age and gender matched children: 62 controls had no dental sealant/resin on their tooth surfaces and 62 cases had more than 4 tooth surfaces with dental sealant/resin. Analysis of covariance (ANCOVA) and conditional logistic regression were performed after controlling for age, gender, salivary flow rate, salivary buffer capacity, frequency of snacking, and frequency of tooth brushing. Salivary BPA levels were 0.002 to 8.305 µg/L. The BPA level of control (0.40 µg/L) was significantly lower than that of case (0.92 µg/L) after controlling for confounders (P = 0.026). Although the 90th BPA percentile had an adjusted OR of 4.58 (95% CI 1.04-20.26, P = 0.045), the significance disappeared in the conditional logistic model. There may be a relationship between salivary BPA level and dental sealant/resin.
越来越多的儿童使用含双酚 A（BPA）衍生物的牙面窝沟封闭剂和复合填充材料。本研究旨在评估唾液 BPA 与牙面窝沟封闭剂/树脂填充数量之间的关系，并确定 BPA 的截断值水平。在 124 名年龄和性别匹配的儿童中，检测了唾液 BPA 浓度和牙面窝沟封闭剂/树脂填充数量：62 名对照者牙面上没有窝沟封闭剂/树脂，62 名病例者牙面上有超过 4 个窝沟封闭剂/树脂填充的牙面。在控制年龄、性别、唾液流率、唾液缓冲能力、零食频率和刷牙频率后，进行协方差分析（ANCOVA）和条件逻辑回归分析。唾液 BPA 水平为 0.002-8.305 µg/L。在控制混杂因素后（P=0.026），对照组（0.40 µg/L）的 BPA 水平明显低于病例组（0.92 µg/L）。虽然第 90 个 BPA 百分位数的调整比值比为 4.58（95%可信区间为 1.04-20.26，P=0.045），但在条件逻辑模型中这种关系消失了。唾液 BPA 水平与牙面窝沟封闭剂/树脂之间可能存在一定关系。
