Joskow Renée, Barr Dana Boyd, Barr John R, Calafat Antonia M, Needham Larry L, Rubin Carol
U.S. Public Health Service, Office of Force Readiness and Deployment, Office of the Surgeon General, Office of the Secretary, U.S. Department of Health and Human Services, Rockville, MD, USA.
J Am Dent Assoc. 2006 Mar;137(3):353-62. doi: 10.14219/jada.archive.2006.0185.
Bisphenol A (BPA) is a common component of composites and dental sealants. The potential exists for human exposure after sealant placement.
The authors prospectively enrolled 15 men in an exposure assessment study; 14 completed the study. After placement of clinically appropriate amounts of one of two sealants, the authors measured BPA in saliva and urine samples collected at prescribed intervals after the sealants were placed. They used selective and sensitive isotope-dilution mass-spectrometry-based methods for BPA measurements, thus providing the most reliable results.
Helioseal F (Ivoclar Vivadent, Amherst, N.Y.) leached negligible amounts of BPA. Urinary and salivary BPA levels in subjects who received these sealants were similar to baseline levels. Delton Light Cure (LC) Opaque pit-and-fissure sealant (Dentsply/Ash, York, Pa.) leached more BPA, resulting in low-level BPA exposures similar to those used in laboratory animal testing. BPA exposure after Delton LC sealant placement was significantly higher than exposure after placement of Helioseal F. Patients treated with Delton LC had significantly higher doses of BPA (110 microg) than did those treated with Helioseal F (5.5 microg) (P < .0001).
Placement of clinically relevant amounts of Delton LC sealant resulted in low-level BPA exposure; however, exposure was negligible after placement of Helioseal F. Saliva collection after sealant placement likely reduced systemic absorption of BPA from dental sealants. Sealants should remain a useful part of routine preventive dental practice, especially those that leach negligible amounts of BPA.
Dental sealants may be a point source for low-level BPA exposure at levels that show health effects in rodents. Further research is required to determine whether human exposure to BPA at these levels causes adverse effects.
双酚A（BPA）是复合材料和牙科密封剂的常见成分。放置密封剂后，人体存在接触BPA的可能性。
作者前瞻性地招募了15名男性参与一项暴露评估研究；14人完成了研究。在放置临床适量的两种密封剂之一后，作者在密封剂放置后的规定时间间隔收集唾液和尿液样本，并测量其中的BPA。他们使用基于选择性和灵敏的同位素稀释质谱法测量BPA，从而提供最可靠的结果。
Helioseal F（义获嘉伟瓦登特公司，纽约州阿默斯特）释放的BPA量可忽略不计。接受这些密封剂的受试者尿液和唾液中的BPA水平与基线水平相似。Delton光固化（LC）不透明窝沟封闭剂（登士柏/阿什公司，宾夕法尼亚州约克）释放的BPA更多，导致低水平的BPA暴露，类似于实验室动物测试中使用的暴露水平。放置Delton LC密封剂后的BPA暴露显著高于放置Helioseal F后的暴露。接受Delton LC治疗的患者的BPA剂量（110微克）显著高于接受Helioseal F治疗的患者（5.5微克）（P <.0001）。
放置临床相关量的Delton LC密封剂导致低水平的BPA暴露；然而，放置Helioseal F后暴露可忽略不计。放置密封剂后收集唾液可能减少了牙科密封剂中BPA的全身吸收。密封剂应仍然是常规预防性牙科实践的有用组成部分，尤其是那些释放BPA量可忽略不计的密封剂。
牙科密封剂可能是低水平BPA暴露的一个来源，这种暴露水平在啮齿动物中显示出健康影响。需要进一步研究以确定人体在这些水平接触BPA是否会产生不良影响。
