Wang Qiushi, Yang Qiaoni, Bai Yingzhe, Zhang Chengxin, Diao Yanni, Fang Deqiang
Department of Blood Transfusion, Shengjing Hospital, China Medical University, Shenyang, China.
Transfus Med Hemother. 2012 Aug;39(4):283-286. doi: 10.1159/000339811. Epub 2012 Jul 5.
The aim of this study was to evaluate the frequency of red blood cell (RBC) alloantibodies in surgical patients. METHODS: Blood samples of 18,980 Chinese surgical patients were collected and tested between January 2009 and September 2010. For patients with RBC alloantibodies, sequences of antibodies were identified with the DiaMed Asia antibody screening system. Data regarding sex, age, transfusion history, pregnancy history, and alloantibody specificity were collected. RESULTS: 39 alloantibodies were identified from 18,980 samples, yielding a prevalence of 0.21%. The most frequently identified alloantibodies were Rhesus system antibodies (28/39, 71.8%), including anti-E (17/39; 1 anti-E accompanied by anti-Fy(b)), anti-c (5/39), anti-cE (2/39), anti-C(w) (1/39), anti-D (1/39), and anti-e (1/39). Other antibodies included anti-M (5/39), anti-Le(a) (2/39), anti-Le(b) (1/39), anti-K+S (1/39), anti-JK(a) (1/39), and anti-JS(a) (1/39). The frequency of alloantibodies was greater in females than in males (31 vs. 8). CONCLUSION: The results show a higher prevalence of RBC alloantibodies in females than in males. Anti-E was the most common alloantibody identified in this Chinese surgical population and was also more frequent in females compared to males.
本研究旨在评估外科手术患者中红细胞（RBC）同种抗体的出现频率。方法：收集了2009年1月至2010年9月期间18980名中国外科手术患者的血样并进行检测。对于存在RBC同种抗体的患者，使用DiaMed Asia抗体筛查系统鉴定抗体序列。收集了有关性别、年龄、输血史、妊娠史和同种抗体特异性的数据。结果：在18980份样本中鉴定出39种同种抗体，发生率为0.21%。最常鉴定出的同种抗体是恒河猴系统抗体（28/39，71.8%），包括抗-E（17/39；1例抗-E伴有抗-Fy(b)）、抗-c（5/39）、抗-cE（2/39）、抗-C(w)（1/39）、抗-D（1/39）和抗-e（1/39）。其他抗体包括抗-M（5/39）、抗-Le(a)（2/39）、抗-Le(b)（1/39）、抗-K+S（1/39）、抗-JK(a)（1/39）和抗-JS(a)（1/）。同种抗体在女性中的出现频率高于男性（31例对8例）。结论：结果显示女性中RBC同种抗体的发生率高于男性。抗-E是在中国该外科手术人群中鉴定出的最常见同种抗体，且在女性中比在男性中更频繁。
