Caamaño José, Musante Evangelina, Contreras Margarita, Ulloa Hernán, Reyes Carolina, Inaipil Verónica, Saavedra Nicolás, Guzmán Neftalí
Banco de Sangre Hospital Dr. Hernán Henríquez Aravena, Temuco, Chile ; Facultad de Salud Universidad Santo Tomás, Temuco, Chile.
Banco de Sangre Hospital Dr. Hernán Henríquez Aravena, Temuco, Chile.
Transfus Med Hemother. 2015 Jan;42(1):4-7. doi: 10.1159/000370136. Epub 2014 Dec 19.
Alloimmunization is an adverse effect of blood transfusions. In Chile, alloimmunization frequency is not established, and for this reason the aim of this study was to investigate the prevalence and specificity of red blood cell (RBC) alloantibodies in Chilean transfused subjects.
Records from 4,716 multi-transfused patients were analyzed. In these patients, antibody screening was carried out prior to cross-matching with a commercially available two-cell panel by the microcolum gel test, and samples with a positive screen were analyzed for the specificity of the alloantibody with a 16-cell identification panel.
The incidence of RBC alloimmunization in transfused patients was 1.02% (48/4,716) with a higher prevalence in women (40/48). We detected 52 antibodies, the most frequent specificities identified were anti-E (30.8%), anti-K (26.9%), anti-D (7.7%), and anti-Fy(a) (5.8%). The highest incidence of alloantibodies was observed in cancer and gastroenterology patients.
The data demonstrated a low alloimmunization frequency in Chilean transfused patients, principally associated with antibodies anti-E, anti-K, anti-D, and anti-Fy(a).
同种免疫是输血的一种不良反应。在智利，同种免疫的发生率尚未确定，因此本研究的目的是调查智利输血患者中红细胞（RBC）同种抗体的患病率和特异性。
分析了4716例多次输血患者的记录。在这些患者中，在通过微柱凝胶试验与市售的双细胞板进行交叉配血之前进行抗体筛查，并用16细胞鉴定板分析筛查呈阳性的样本中同种抗体的特异性。
输血患者中红细胞同种免疫的发生率为1.02%（48/4716），女性患病率较高（40/48）。我们检测到52种抗体，最常见的特异性为抗-E（30.8%）、抗-K（26.9%）、抗-D（7.7%）和抗-Fy(a)（5.8%）。在癌症和胃肠病患者中观察到同种抗体的最高发生率。
数据表明智利输血患者的同种免疫频率较低，主要与抗-E、抗-K、抗-D和抗-Fy(a)抗体有关。
