在感染流感病毒和呼吸道合胞病毒的小鼠中给予IP-10后肺部炎症的病理学观察。
Pathological observations of lung inflammation after administration of IP-10 in influenza virus- and respiratory syncytial virus-infected mice.
作者信息
Luo Hong, Wang Dong, Che Hai-Long, Zhao Yue, Jin Hong
机构信息
Department of Microbiology and Parasitology, China Medical University, Shenyang 110001;
出版信息
Exp Ther Med. 2012 Jan;3(1):76-79. doi: 10.3892/etm.2011.350. Epub 2011 Sep 9.
Abstract
Pneumonia is a common complication of influenza virus infection and a common cause of death of patients. The aim of this study was to test the hypothesis that interferon-γ-inducible protein-10 (IP-10) is an important chemokine in the development of airway inflammation caused by certain viruses. Mice were infected with influenza virus after administration of murine IP-10 and the severity of pneumonia was compared with the group which was infected with influenza virus alone. Another mice group was infected with respiratory syncytial virus (RSV) after injection of IP-10 and also the severity of pneumonia was compared to the group which was infected with RSV alone. The mice infected with influenza virus or RSV after administration of IP-10 presented with more fulminant and necrotizing diffuse alveolar and bronchiole damage with lymphocyte infiltration. Our results indicate that IP-10 is an important chemokine and is associated with the severity of pneumonia caused by certain viruses.
摘要
肺炎是流感病毒感染的常见并发症，也是患者死亡的常见原因。本研究的目的是验证以下假设：γ-干扰素诱导蛋白10（IP-10）是某些病毒引起气道炎症过程中的一种重要趋化因子。给小鼠注射鼠源IP-10后再感染流感病毒，并将肺炎严重程度与单纯感染流感病毒的组进行比较。另一组小鼠在注射IP-10后感染呼吸道合胞病毒（RSV），同样将肺炎严重程度与单纯感染RSV的组进行比较。注射IP-10后感染流感病毒或RSV的小鼠出现更严重的暴发性坏死性弥漫性肺泡和细支气管损伤，并伴有淋巴细胞浸润。我们的结果表明，IP-10是一种重要的趋化因子，与某些病毒引起的肺炎严重程度相关。
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