Hirao Tomomi, Koikawa Natsue, Aoki Kazuhiro, Sakuraba Keishoku, Shimmura Yuki, Suzuki Yoshio, Sawaki Keisuke
Department of Sports Science, School of Health and Sports Science, Juntendo University, Chiba 270-1695;
Exp Ther Med. 2012 Apr;3(4):641-644. doi: 10.3892/etm.2012.446. Epub 2012 Jan 9.
Wheat gluten hydrolysate (WGH) is rich in glutamyl residue; glutamine is considered a conditionally essential amino acid under physical stress. WGH has been reported to suppress post-exercise rises in serum creatine kinase in male distance runners. This study aimed to reproduce the effects in female distance runners under similar conditions. The study was conducted in a double-blinded crossover manner. Six female collegiate distance runners ingested WGH or a placebo after a 2-h run at an intensity estimated as 60-70% of their maximum oxygen uptake. Blood was sampled before, immediately after, and at 10 and 24 h after the run. Unlike those in male runners, serum creatine kinase (CK) increased slightly, with a peak at 10 h after the run, while plasma glutamine kept declining. The anti-inflammatory effect of WGH was not evident since the post-exercise elevation of CK was ambiguous. Plasma glutamine concentrations also showed a different kinetics from that in men.
小麦麸质水解物（WGH）富含谷氨酰胺残基；在身体应激状态下，谷氨酰胺被认为是一种条件必需氨基酸。据报道，WGH可抑制男性长跑运动员运动后血清肌酸激酶的升高。本研究旨在在相似条件下重现对女性长跑运动员的影响。该研究采用双盲交叉方式进行。六名女性大学长跑运动员在以估计为其最大摄氧量60 - 70%的强度进行2小时跑步后，摄入WGH或安慰剂。在跑步前、跑步后即刻、跑步后10小时和24小时采集血液样本。与男性运动员不同，血清肌酸激酶（CK）略有升高，在跑步后10小时达到峰值，而血浆谷氨酰胺持续下降。由于运动后CK升高不明确，WGH的抗炎作用不明显。血浆谷氨酰胺浓度的动力学变化也与男性不同。
