Ng Sze-How, Wong Kai-Pun, Lang Brian Hung-Hin
Breast and Endocrine Unit, Department of Surgery, Kuala Lumpur Hospital, 50586 Kuala Lumpur, Malaysia.
J Thyroid Res. 2012;2012:946276. doi: 10.1155/2012/946276. Epub 2012 Aug 16.
An increasing elderly population, a rising incidence of differentiated thyroid carcinoma (DTC), and a rising incidence of benign nodular disease with age are all contributing to a rise in thyroid operations for the elderly. Literature review on the outcome and safety of thyroid surgery in elderly patients has been filled with conflicting results and this subject remains controversial. Although most single-institution studies conducted by high-volume surgeons did not find significant differences of complication rates in elderly when compared with younger cohorts, they often lacked the power necessary to identify subtle differences and suffered from various selection and referral biases. Recent evidence from large population-based studies concluded that thyroid surgery in the elderly was associated with higher complication rates. One of the major contributing factors for the increased complication rate was because most elderly patients suffered from many preexisting comorbidities. Therefore, elderly patients who have abnormal thyroid findings should complete a thorough preoperative workup and better postoperative care after undergoing any thyroid surgery. Furthermore, these high-risk patients would benefit if they could be referred to high-volume, specialized surgical units early. In this systemic review, we aimed to evaluate different issues and controversies in thyroidectomy for elderly patients.
老年人口不断增加、分化型甲状腺癌(DTC)发病率上升以及良性结节性疾病发病率随年龄增长而上升,这些都导致了老年甲状腺手术量的增加。关于老年患者甲状腺手术结果和安全性的文献综述结果相互矛盾,这一话题仍存在争议。尽管大多数由高手术量外科医生进行的单机构研究未发现老年患者与年轻患者在并发症发生率上有显著差异,但这些研究往往缺乏识别细微差异所需的能力,且存在各种选择和转诊偏倚。基于大量人群研究的最新证据表明,老年患者的甲状腺手术与更高的并发症发生率相关。并发症发生率增加的一个主要因素是,大多数老年患者患有多种并存的合并症。因此,甲状腺检查结果异常的老年患者在接受任何甲状腺手术后,都应进行全面的术前检查并接受更好的术后护理。此外,如果这些高危患者能够尽早转诊至高手术量的专业外科科室,他们将从中受益。在本系统综述中,我们旨在评估老年患者甲状腺切除术的不同问题和争议。