Dittman B, Wimmer R, Mindermann R, Ohlsson K
Adv Exp Med Biol. 1979;120B:297-304.
From the results obtained in preliminary in vitro experiments we may conclude that the unspecific breakdown of kininogens by neutral and acidic granulocytic proteinases may occur also in the organism during pathological conditions. Inhibitor application may serve as a valuable tool to prevent unspecific proteolytic degradation and thus elimination of kininogens and other clotting or complement factors from their biological function. Furthermore, specific cleavage products of the kininogens produced by granulocytic enzymes may be useful in the diagnosis of a beginning septicemia as well as in elucidation of the primary structure of the human kininogens.
从初步体外实验获得的结果中，我们可以得出结论，在病理状态下，中性和酸性粒细胞蛋白酶对激肽原的非特异性降解也可能在生物体内发生。应用抑制剂可能是防止非特异性蛋白水解降解从而避免激肽原及其他凝血或补体因子丧失生物学功能的一种有价值的手段。此外，粒细胞酶产生的激肽原特异性裂解产物可能有助于早期败血症的诊断以及阐明人激肽原的一级结构。
