Department of Medical Informatics and Clinical Epidemiology and Evidence-based Practice Center, School of Medicine, Oregon Health & Science University, Portland, OR, USA.
BMC Med Res Methodol. 2012 Sep 12;12:140. doi: 10.1186/1471-2288-12-140.
The Drug Effectiveness Review Project was initiated in 2003 in response to dramatic increases in the cost of pharmaceuticals, which lessened the purchasing power of state Medicaid budgets. A collaborative group of state Medicaid agencies and other organizations formed to commission high-quality comparative effectiveness reviews to inform evidence-based decisions about drugs that would be available to Medicaid recipients. The Project is coordinated by the Center for Evidence-based Policy (CEbP) at Oregon Health & Science University (OHSU), and the systematic reviews are undertaken by the Evidence-based Practice Centers (EPCs) at OHSU and at the University of North Carolina. The reviews adhere to high standards for comparative effectiveness reviews. Because the investigators have direct, regular communication with policy-makers, the reports have direct impact on policy and decision-making, unlike many systematic reviews. The Project was an innovator of methods to involve stakeholders and continues to develop its methods in conducting reviews that are highly relevant to policy-makers. The methods used for selecting topics, developing key questions, searching, determining eligibility of studies, assessing study quality, conducting qualitative and quantitative syntheses, rating the strength of evidence, and summarizing findings are described. In addition, our on-going interactions with the policy-makers that use the reports are described.
药品实效审查计划于 2003 年启动，以应对药品成本的大幅上涨，这降低了州医疗补助预算的购买力。一个由州医疗补助机构和其他组织组成的合作团体成立，委托进行高质量的药物比较实效审查，为医疗补助受助人提供药物的循证决策。该计划由俄勒冈健康与科学大学（OHSU）的循证政策中心（CEbP）协调，系统审查由 OHSU 和北卡罗来纳大学的循证实践中心（EPCs）进行。这些审查符合比较实效审查的高标准。由于研究人员与政策制定者直接、定期沟通，报告对政策和决策具有直接影响，这与许多系统审查不同。该计划是采用方法来让利益相关者参与的创新者，并继续开发其方法，以进行与政策制定者高度相关的审查。描述了用于选择主题、制定关键问题、搜索、确定研究资格、评估研究质量、进行定性和定量综合、评估证据强度以及总结研究结果的方法。此外，还描述了我们与使用报告的政策制定者的持续互动。
