Clinical Breast Care Project, Henry M Jackson Foundation for the Advancement of Military Medicine, Windber, PA 15963, USA.
Expert Rev Pharmacoecon Outcomes Res. 2012 Aug;12(4):451-64. doi: 10.1586/erp.12.37.
Advances in diagnostic screening and adjuvant therapy have dramatically increased the number of breast cancer survivors in the USA, who may face changes in physical and mental health, social support, quality of life and economics. Women living with breast cancer are increasingly interested in lifestyle modification to decrease the risk of recurrence and mortality while increasing physical and emotional wellbeing. Although organizations such as the American Cancer Society support a healthy diet, frequent physical activity and stress reduction for decreasing breast cancer risk, studies examining the effects of lifestyle on clinical outcomes including survival and prognosis have been inconclusive. With the number of breast cancer survivors predicted to increase to 3.4 million by 2015, it is important to develop effective treatment paradigms that overcome barriers to behavioral modification to improve clinical outcomes and survivorship in breast cancer patients.
在美国,诊断筛查和辅助治疗的进步显著增加了乳腺癌幸存者的数量,他们可能面临身心健康、社会支持、生活质量和经济状况的变化。患有乳腺癌的女性越来越关注生活方式的改变,以降低复发和死亡的风险,同时提高身体和情绪的健康。尽管美国癌症协会等组织支持健康饮食、经常进行身体活动和减轻压力来降低乳腺癌风险,但研究生活方式对包括生存和预后在内的临床结果的影响尚无定论。预计到 2015 年,乳腺癌幸存者的数量将增加到 340 万,因此开发有效的治疗模式以克服行为改变的障碍,改善乳腺癌患者的临床结果和生存状况非常重要。