Department of Science and Technology, University of the Witwatersrand, Johannesburg, Gauteng, South Africa.
Expert Rev Respir Med. 2012 Aug;6(4):451-65. doi: 10.1586/ers.12.32.
The interactions between Streptococcus pneumoniae and other respiratory pathogens have been studied in vitro, in animal models and in humans - including epidemiologic and vaccine probe studies. Interactions of pneumococcus with respiratory viruses are common, and many mechanisms have been suggested to explain this phenomenon. The aim of this review is to explore pneumococcal interactions with respiratory viruses and consider the potential role that the pneumococcal polysaccharide-protein conjugate vaccine may play in modifying pneumococcal-respiratory viral interactions.
肺炎链球菌与其他呼吸道病原体之间的相互作用已在体外、动物模型和人类中进行了研究，包括流行病学和疫苗研究。肺炎球菌与呼吸道病毒的相互作用很常见，已经提出了许多机制来解释这一现象。本综述的目的是探讨肺炎球菌与呼吸道病毒的相互作用，并考虑肺炎球菌多糖蛋白结合疫苗可能在改变肺炎球菌-呼吸道病毒相互作用方面发挥的作用。
