Institute of Life Sciences, Laboratory for Nanomedicine, Nalco Square, Bhubaneswar, Orissa, 751023, India.
Expert Opin Drug Deliv. 2012 Nov;9(11):1347-64. doi: 10.1517/17425247.2012.724676. Epub 2012 Sep 13.
Curcumin is a safe, affordable and natural bioactive molecule of turmeric (Curcuma longa). It has gained considerable attention in recent years for its multiple pharmacological activities. However, its optimum pharmaceutical potential has been limited by its lack of aqueous solubility and poor bioavailability. To mitigate the above limitations, recently various nanostructured water-soluble delivery systems were developed to increase the solubility and bioavailability of curcumin.
Major reasons contributing to the low bioavailability of curcumin appear to be owing to its poor solubility, low absorption, rapid metabolism and rapid systemic elimination. The present review summarizes the strategies using curcumin in various nanocarrier delivery systems to overcome poor solubility and inconsistent bioavailability of curcumin and describes the current status and challenges for the future.
The development of various drug delivery systems to deliver curcumin will certainly provide a step up towards augmenting the therapeutic activity of curcumin thereby increasing the solubility and bioavailability of curcumin. However, the future of such delivery technology will be highly dependent on the development of safe, non-toxic and non-immunogenic nanocarriers.
姜黄素是姜黄（Curcuma longa）中的一种安全、实惠且天然的生物活性分子。近年来，由于其多种药理作用，它受到了广泛关注。然而，由于其水溶性差和生物利用度低，其最佳的药用潜力受到了限制。为了减轻上述限制，最近开发了各种纳米结构的水溶性递送系统，以提高姜黄素的溶解度和生物利用度。
导致姜黄素生物利用度低的主要原因似乎是其溶解度差、吸收低、代谢快和系统消除快。本综述总结了在各种纳米载体递送系统中使用姜黄素的策略，以克服姜黄素溶解度差和生物利用度不一致的问题，并描述了未来的现状和挑战。
开发各种药物递送系统来递送姜黄素，必将有助于提高姜黄素的治疗活性，从而提高姜黄素的溶解度和生物利用度。然而，这种递送技术的未来在很大程度上取决于安全、无毒和非免疫原性纳米载体的开发。
