Department of Basic Science, Islamic Azad University of Damghan, Damghan, Iran.
Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
J Cell Physiol. 2019 Aug;234(8):12325-12340. doi: 10.1002/jcp.28024. Epub 2019 Jan 30.
Effective drug delivery is one of the most important issues associated with the administration of therapeutic agents that have low oral bioavailability. Curcumin is an active ingredient in the turmeric plant, which has low oral bioavailability due to its poor aqueous solubility. One strategy that has been considered for enhancing the aqueous solubility, and, thus, its oral bioavailability, is the use of chitosan as a carrier for curcumin. Chitosan is a biodegradable and biocompatible polymer that is relatively water-soluble. Therefore, various studies have sought to improve the aqueous solubility of chitosan. The use of different pharmaceutical excipients and formulation strategies has the potential to improve aqueous solubility, formulation processing, and the overall delivery of hydrophobic drugs. This review focuses on various methods utilized for chitosan-based delivery of curcumin.
有效的药物递送是与具有低口服生物利用度的治疗剂给药相关的最重要问题之一。姜黄素是姜黄植物中的一种活性成分，由于其水溶性差，口服生物利用度低。一种被认为可以提高水溶解度，从而提高其口服生物利用度的策略是使用壳聚糖作为姜黄素的载体。壳聚糖是一种可生物降解和生物相容的聚合物，相对水溶性较好。因此，各种研究都试图提高壳聚糖的水溶解度。使用不同的药用辅料和制剂策略有可能提高水溶解度、制剂加工和疏水性药物的整体递送。本综述重点介绍了用于壳聚糖递送姜黄素的各种方法。
