Laboratory for Infectious Diseases and Screening, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
Euro Surveill. 2012 Sep 6;17(36):20266.
Two Dutch travellers were infected with oseltamivir-resistant influenza A(H1N1)pdm09 viruses with an H275Y neuraminidase substitution in early August 2012. Both cases were probably infected during separate holidays at the Catalonian coast (Spain). No epidemiological connection between the two cases was found, and neither of them was treated with oseltamivir before specimen collection. Genetic analysis of the neuraminidase gene revealed the presence of previously described permissive mutations that may increase the likelihood of such strains emerging and spreading widely.
2012 年 8 月初，两名荷兰旅行者感染了具有神经氨酸酶 H275Y 取代的奥司他韦耐药甲型 H1N1pdm09 病毒。两例病例可能是在加泰罗尼亚（西班牙）沿海度假期间分别感染的。在采集标本之前，两例病例均未使用奥司他韦进行治疗，且两例病例之间未发现流行病学联系。对神经氨酸酶基因的遗传分析显示存在先前描述的允许性突变，这可能增加了此类菌株出现和广泛传播的可能性。
