血清视黄醇结合蛋白4水平升高可能是中国2型糖尿病患者代谢控制不佳的一个预测指标。

Higher serum retinol binding protein 4 may be a predictor of weak metabolic control in chinese patients with type 2 diabetes mellitus.

作者信息

Wang M N, Han Y B, Li Q, Guo L, Yang Y M, Wang W, Zhang J C

机构信息

Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Harbin Medical University and The Key Laboratory of Hormonal and Endocrine Diseases, Harbin Medical University, Harbin, Heilongjiang Province, China.

出版信息

J Int Med Res. 2012;40(4):1317-24. doi: 10.1177/147323001204000410.

DOI:10.1177/147323001204000410

PMID:22971483

Abstract

OBJECTIVE

To investigate relationships between serum levels of retinol binding protein 4 (RBP4) and clinical and metabolic variables in Chinese patients with type 2 diabetes mellitus.

METHODS

A total of 513 patients (286 males/227 females) provided clinical and lifestyle data and blood and urine samples for analysis. Patients were stratified into four quartile groups according to serum RBP4 concentrations.

RESULTS

RBP4 concentration was independently associated with gender, systolic blood pressure, serum triglyceride and creatinine levels, and estimated glomerular filtration rate (eGFR). Hypertension, dyslipidaemia, micro albuminuria and impaired eGFR (<60 ml/min per 1.73 m2) were significantly more prevalent in patients with the highest RBP4 levels than in those with the lowest levels. Increased serum RBP4 was associated with increased risk of hypertension, dyslipidaemia, micro albuminuria and impaired eGFR after adjusting for gender, age, body mass index and duration of diabetes.

CONCLUSION

Serum RBP4 may be a useful marker of overall metabolic control in Chinese patients with type 2 diabetes mellitus.

摘要

目的

探讨中国2型糖尿病患者血清视黄醇结合蛋白4（RBP4）水平与临床及代谢变量之间的关系。

方法

共有513例患者（286例男性/227例女性）提供了临床和生活方式数据以及血液和尿液样本用于分析。根据血清RBP4浓度将患者分为四个四分位数组。

结果

RBP4浓度与性别、收缩压、血清甘油三酯和肌酐水平以及估计肾小球滤过率（eGFR）独立相关。RBP4水平最高的患者中，高血压、血脂异常、微量白蛋白尿和eGFR受损（<60 ml/min per 1.73 m2）的患病率显著高于水平最低的患者。在调整性别、年龄、体重指数和糖尿病病程后，血清RBP4升高与高血压、血脂异常、微量白蛋白尿和eGFR受损风险增加相关。