视黄醇结合蛋白4与饮食、炎症、免疫及心血管疾病的关系
Retinol binding protein 4 in relation to diet, inflammation, immunity, and cardiovascular diseases.
作者信息
Zabetian-Targhi Fateme, Mahmoudi Mohammad J, Rezaei Nima, Mahmoudi Maryam
机构信息
Department of Cellular Molecular Nutrition, School of Nutritional Sciences and Dietetics and.
Division of Cardiology, Department of Internal Medicine and.
出版信息
Adv Nutr. 2015 Nov 13;6(6):748-62. doi: 10.3945/an.115.008292. Print 2015 Nov.
Abstract
Retinol binding protein 4 (RBP4), previously called retinol binding protein (RBP), is considered a specific carrier of retinol in the blood. It is also an adipokine that has been implicated in the pathophysiology of insulin resistance. RBP4 seems to be correlated with cardiometabolic markers in inflammatory chronic diseases, including obesity, type 2 diabetes, metabolic syndrome, and cardiovascular diseases (CVDs). It has recently been suggested that inflammation produced by RBP4 induces insulin resistance and CVD. The clinical relevance of this hypothesis is discussed in this review. Knowledge concerning the association of RBP4 with inflammation markers, oxidative stress, and CVDs as well as concerning the role of diet and antioxidants in decreasing RBP4 concentrations are discussed. Special attention is given to methodologies used in previously published studies and covariates that should be controlled when planning new studies on this adipokine.
摘要
视黄醇结合蛋白4（RBP4），以前称为视黄醇结合蛋白（RBP），被认为是血液中视黄醇的特异性载体。它也是一种脂肪因子，与胰岛素抵抗的病理生理学有关。RBP4似乎与炎症性慢性疾病中的心脏代谢标志物相关，包括肥胖、2型糖尿病、代谢综合征和心血管疾病（CVD）。最近有人提出，RBP4产生的炎症会诱导胰岛素抵抗和心血管疾病。本综述讨论了这一假说的临床相关性。讨论了有关RBP4与炎症标志物、氧化应激和心血管疾病的关联，以及饮食和抗氧化剂在降低RBP4浓度方面的作用的知识。特别关注先前发表的研究中使用的方法以及在规划关于这种脂肪因子的新研究时应控制的协变量。
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