Mori Akihiro, Kurishima Miyuki, Oda Hitomi, Saeki Kaori, Arai Toshiro, Sako Toshinori
Department of Veterinary Nursing & Technology, School of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino, Tokyo 180-8602, Japan.
J Vet Med Sci. 2013 Jan 31;75(1):113-7. doi: 10.1292/jvms.12-0123. Epub 2012 Oct 10.
Monitoring of blood glucose concentration is important to evaluate the diabetic status of dogs. Continuous glucose monitoring systems (CGMS) have been applied in veterinary medicine for glucose monitoring in diabetic dogs. The purpose of the study was to evaluate the daily glycemic profiles obtained with CGMS and compare glucose fluctuations between day- and night-time in diabetic dogs. Five diabetic dogs were used in this study and were treated with either NPH insulin or insulin detemir. For data analyses, day-time was defined as 9:00 am-9:00 pm and night-time as 9:00 pm-9:00 am. Using glucose profiles, we determined the mean glucose concentrations (1- and 12-hr intervals), and times spent in hyperglycemia >200 mg/dl or hypoglycemia <60 mg/dl. None of the parameters differed significantly between day-time and night-time in dogs treated with NPH insulin or insulin detemir. In conclusion, this study confirmed, using CGMS, that there are no differences in glucose fluctuations between day- and night-time, in diabetic dogs on a similar feeding regimen and insulin administration.
监测血糖浓度对于评估犬类的糖尿病状况很重要。连续血糖监测系统（CGMS）已应用于兽医学中，用于监测糖尿病犬的血糖。本研究的目的是评估通过CGMS获得的每日血糖谱，并比较糖尿病犬白天和夜间的血糖波动情况。本研究使用了五只糖尿病犬，分别用中性鱼精蛋白锌胰岛素（NPH胰岛素）或地特胰岛素进行治疗。数据分析时，白天定义为上午9:00至晚上9:00，夜间定义为晚上9:00至上午9:00。利用血糖谱，我们确定了平均血糖浓度（1小时和12小时间隔），以及血糖高于200mg/dl的高血糖或低于60mg/dl的低血糖持续时间。在用NPH胰岛素或地特胰岛素治疗的犬中，白天和夜间的各项参数均无显著差异。总之，本研究使用CGMS证实，在相似的喂养方案和胰岛素给药情况下，糖尿病犬白天和夜间的血糖波动没有差异。
