Department of Clinical Medicine, Griffith University, Postal Address 5/123 Nerang St, Southport, Queensland 4215, Australia.
Curr Allergy Asthma Rep. 2013 Feb;13(1):93-100. doi: 10.1007/s11882-012-0301-4.
The transient receptor potential (TRP) superfamily consists of 28 members in mammals (27 in human) that act as polymodal sensors and ion channels. They regulate cellular calcium influx, generate depolarization thereby triggering voltage dependent cellular processes, and in turn they are critical in inducing the metabolic activities of cells. It is increasingly apparent that many of the inflammatory mediators released in allergic reactions involve at least two of these ion channels, the 'Vanilloid' TRPV1 and the 'Ankyrin" TRPA1. This review mainly focuses on TRPV1 and TRPA1 and the role they have in the allergic response and how these receptors may be influenced in exercise-induced anaphylaxis. The threshold to react to an allergen for mast cells and lymphocytes can be reduced by activating the melastatin channel TRPM4. This channel is briefly discussed in the context of allergy.
瞬时受体电位 (TRP) 超家族由哺乳动物中的 28 个成员组成（人类有 27 个），它们作为多模态传感器和离子通道发挥作用。它们调节细胞内钙离子内流，产生去极化从而触发电压依赖性细胞过程，反过来又在诱导细胞代谢活动方面起着至关重要的作用。越来越明显的是，过敏反应中释放的许多炎症介质至少涉及其中两种离子通道，即“香草醛” TRPV1 和“锚蛋白” TRPA1。本综述主要关注 TRPV1 和 TRPA1 及其在过敏反应中的作用，以及这些受体在运动诱发过敏反应中可能受到的影响。通过激活黑素瘤通道 TRPM4，可以降低肥大细胞和淋巴细胞对过敏原反应的阈值。在过敏的背景下简要讨论了该通道。
