Laboratory Ion Channel Research and TRP Research Platform Leuven (TRPLe), KU Leuven, Campus Gasthuisberg, Leuven, Belgium.
Compr Physiol. 2012 Jan;2(1):563-608. doi: 10.1002/cphy.c110026.
TRP channels constitute a large superfamily of cation channel forming proteins, all related to the gene product of the transient receptor potential (trp) locus in Drosophila. In mammals, 28 different TRP channel genes have been identified, which exhibit a large variety of functional properties and play diverse cellular and physiological roles. In this article, we provide a brief and systematic summary of expression, function, and (patho)physiological role of the mammalian TRP channels.
TRP 通道构成了一个大型阳离子通道形成蛋白超家族，所有这些蛋白都与果蝇中的瞬时受体电位（TRP）基因座的基因产物有关。在哺乳动物中，已经鉴定出 28 种不同的 TRP 通道基因，它们表现出多种功能特性，并在细胞和生理功能中发挥多样化的作用。在本文中，我们简要而系统地总结了哺乳动物 TRP 通道的表达、功能和（病理）生理作用。
