富自体血小板血浆对感染性角膜炎后持续性角膜上皮缺损的影响。
Effect of autologous platelet-rich plasma on persistent corneal epithelial defect after infectious keratitis.
机构信息
Nune Eye Hospital, Daegu, South Korea.
出版信息
Jpn J Ophthalmol. 2012 Nov;56(6):544-50. doi: 10.1007/s10384-012-0175-y. Epub 2012 Sep 13.
PURPOSE
Platelet-rich plasma (PRP) harbors high concentrations of growth factors related to the promotion of wound healing. We evaluated the efficacy of PRP eyedrops in the treatment of persistent epithelial defects (PEDs).
METHODS
Autologous PRP and autologous serum (AS) were prepared from whole blood. The concentrations of transforming growth factor (TGF)-β1, TGF-β2, epidermal growth factor (EGF), vitamin A and fibronectin in the PRP and AS were analyzed and compared. The corneal epithelial healing efficacy of PRP was compared with that of AS in patients with PED induced by post-infectious inflammation.
RESULTS
The concentrations of TGF-β1, TGF-β2, EGF, vitamin A and fibronectin in the PRP and AS were not statistically different. However, the concentrations of EGF in the PRP were significantly greater than in the AS. AS was used in 17 and PRP in 11 eyes of 28 patients. The healing rates of the corneal epithelia of the PRP-treated eyes were significantly higher than those treated with AS.
CONCLUSIONS
The PRP was effective in the treatment of PEDs. This may be attributable to its high concentration of platelet-contained growth factors, most notably EGF. PRP could be an effective, novel treatment option for chronic ocular surface disease.
目的
富含血小板的血浆（PRP）中含有高浓度的与促进伤口愈合相关的生长因子。我们评估了 PRP 滴眼液治疗持续性上皮缺损（PED）的疗效。
方法
从全血中制备自体 PRP 和自体血清（AS）。分析和比较 PRP 和 AS 中转化生长因子（TGF）-β1、TGF-β2、表皮生长因子（EGF）、维生素 A 和纤维连接蛋白的浓度。将 PRP 与 AS 在感染后炎症引起的 PED 患者中的角膜上皮愈合效果进行比较。
结果
PRP 和 AS 中的 TGF-β1、TGF-β2、EGF、维生素 A 和纤维连接蛋白浓度无统计学差异。然而，PRP 中的 EGF 浓度明显高于 AS。28 例患者中，17 只眼使用 AS，11 只眼使用 PRP。PRP 治疗眼的角膜上皮愈合率明显高于 AS 治疗眼。
结论
PRP 治疗 PED 有效。这可能归因于其高浓度的血小板源性生长因子，尤其是 EGF。PRP 可能是治疗慢性眼表疾病的一种有效、新颖的治疗选择。
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