Kaur G, Raj S M
Departments of Pathology and Medicine, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.
Malays J Med Sci. 2001 Jan;8(1):31-3.
Helicobacter pylori-associated gastric carcinoma is generally more common in the antrum/body and is of the intestinal type. The aim of this study was to determine the pattern of gastric carcinoma in an area known to have a low prevalence of H. pylori. Pathology records of gastric carcinoma diagnosed at Hospital University Sains Malaysia between 1995 and 1999 were retrieved and studied. There were a total of 23 cases. The median age was 60 years. Eighteen patients were Malay and 5 were Chinese. The most common location of the tumour was the cardia/gastrooesophageal junction (61%, 14/23 patients). The majority was of the intestinal type (69.6%, 16/23). The frequency of gastric carcinoma appears to be exceptionally low in the area of study. The Chinese population was over-represented. The higher frequency of tumour in the cardia/gastro-oesophageal junction as compared to the antrum and body is in sharp contrast to most other studies. This reaffirms the notion that Helicobacter pylori infection is a causative agent for non-cardia gastric carcinomas.
幽门螺杆菌相关的胃癌通常在胃窦/胃体更为常见，且为肠型。本研究的目的是确定在一个已知幽门螺杆菌感染率较低的地区胃癌的发病模式。检索并研究了1995年至1999年期间马来西亚理科大学医院诊断的胃癌病理记录。共有23例病例。中位年龄为60岁。18例患者为马来人，5例为华人。肿瘤最常见的部位是贲门/胃食管交界处（61%，14/23例患者）。大多数为肠型（69.6%，16/23）。在研究区域，胃癌的发病率似乎异常低。华人人口占比过高。与胃窦和胃体相比，贲门/胃食管交界处肿瘤的发生率更高，这与大多数其他研究形成鲜明对比。这再次证实了幽门螺杆菌感染是导致非贲门部胃癌的病因这一观点。
