Uyub A M, Raj S M, Visvanathan R, Nazim M, Aiyar S, Anuar A K, Mansur M
Dept. of Microbiology/Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan.
Scand J Gastroenterol. 1994 Mar;29(3):209-13. doi: 10.3109/00365529409090465.
The prevalence of Helicobacter pylori infection was determined in peptic ulcer patients, in non-ulcer dyspepsia (NUD) patients, and in the general adult population. The H. pylori infection rate ascertained by microbiologic examination of multiple gastric antral biopsy specimens was 50% (17 of 34) in duodenal ulcer (DU), 5% (1 of 22) in gastric ulcer, and 9% (15 of 159) in NUD patients. A seroepidemiologic survey showed a prevalence of only 4.2% among 496 blood donors and 4.8% among 921 subjects who attended health screening clinics. H. pylori infection is relatively uncommon and does not appear to be the predominant factor in the pathogenesis of peptic ulcer disease in the area. The incidence of peptic ulcer perforations in the area in 1991-92 was 1.5 per 100,000 person-years, reflecting a relatively low frequency of peptic ulcers, which might be due to the low prevalence of H. pylori infection in the population.
研究测定了消化性溃疡患者、非溃疡性消化不良（NUD）患者以及普通成年人群中幽门螺杆菌感染的患病率。通过对多个胃窦活检标本进行微生物学检查确定的幽门螺杆菌感染率，十二指肠溃疡（DU）患者为50%（34例中的17例），胃溃疡患者为5%（22例中的1例），NUD患者为9%（159例中的15例）。一项血清流行病学调查显示，在496名献血者中患病率仅为4.2%，在921名参加健康筛查门诊的受试者中患病率为4.8%。幽门螺杆菌感染相对不常见，似乎不是该地区消化性溃疡疾病发病机制中的主要因素。1991 - 1992年该地区消化性溃疡穿孔的发病率为每10万人年1.5例，这反映出消化性溃疡的发病率相对较低，这可能是由于人群中幽门螺杆菌感染率较低所致。
