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糖尿病女性中的血管疾病：为何她们失去了女性的保护作用？

Vascular disease in diabetic women: Why do they miss the female protection?

作者信息

Dantas Ana Paula Villela, Fortes Zuleica Bruno, de Carvalho Maria Helena Catelli

机构信息

Experimental Cardiology Division, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) and Institut Clínic de Tòrax, C/Casanova 143 Laboratory, IDIBAPS 404, Hospital Clinic, 08036 Barcelona, Spain.

出版信息

Exp Diabetes Res. 2012;2012:570598. doi: 10.1155/2012/570598. Epub 2012 Sep 3.

DOI:10.1155/2012/570598
PMID:22973304
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3438753/
Abstract

Gender plays a pivotal role in the onset as well as in the progression of the cardiovascular disease with a higher morbidity and mortality being detected in men with respect to women. Type 2 Diabetes Mellitus (T2DM) may reduce gender-related differences in the prevalence of cardiovascular disease by fading the vascular protective effects afforded by estrogen in females. This article will discuss the role of sex and sex hormones on the incidence and mechanisms involved in vascular dysfunction associated to T2DM, which might explain why women with T2DM lack the vascular protection.

摘要

性别在心血管疾病的发病及进展过程中起着关键作用，男性的发病率和死亡率高于女性。2型糖尿病（T2DM）可能会削弱雌激素对女性的血管保护作用，从而减少心血管疾病患病率方面的性别差异。本文将探讨性别和性激素在T2DM相关血管功能障碍的发病及机制中的作用，这或许可以解释为何T2DM女性缺乏血管保护。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b7c/3438753/27d81fc06072/EDR2012-570598.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b7c/3438753/5a3003b53b8f/EDR2012-570598.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b7c/3438753/27d81fc06072/EDR2012-570598.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b7c/3438753/5a3003b53b8f/EDR2012-570598.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b7c/3438753/27d81fc06072/EDR2012-570598.002.jpg

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本文引用的文献

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Effects of estrogen on vascular inflammation: a matter of timing.雌激素对血管炎症的影响：时机问题。
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Mechanisms of endothelial dysfunction in obesity-associated hypertension.肥胖相关性高血压中内皮功能障碍的机制。
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Gender and the extent of coronary atherosclerosis, plaque composition, and clinical outcomes in acute coronary syndromes.
氧化应激对糖尿病患者心肌功能的影响：关注亚临床左心室功能障碍。
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Influence of Gender in Diabetes Mellitus and Its Complication.性别对糖尿病及其并发症的影响。
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Change in Circulating Levels of Endothelial Progenitor Cells and Sexual Function in Women With Type 1 Diabetes.1 型糖尿病女性循环内皮祖细胞水平变化与性功能。
J Clin Endocrinol Metab. 2022 Aug 18;107(9):e3910-e3918. doi: 10.1210/clinem/dgac316.
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Sex Differences of the Diabetic Heart.糖尿病心脏的性别差异
Front Physiol. 2021 May 27;12:661297. doi: 10.3389/fphys.2021.661297. eCollection 2021.
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Gender Differences in Diabetic Kidney Disease: Focus on Hormonal, Genetic and Clinical Factors.性别差异与糖尿病肾病：关注激素、遗传和临床因素。
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Cardiovascular metabolic syndrome: mediators involved in the pathophysiology from obesity to coronary heart disease.心血管代谢综合征：肥胖到冠心病病理生理学中的相关介质。
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Aging negatively affects estrogens-mediated effects on nitric oxide bioavailability by shifting ERα/ERβ balance in female mice.衰老是通过改变雌性小鼠 ERα/ERβ 平衡，对雌激素介导的一氧化氮生物利用度产生负面影响。
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