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通过镁预处理预防麻醉诱导中依托咪酯相关的肌阵挛。

Prevention of etomidate-related myoclonus in anesthetic induction by pretreatment with magnesium.

作者信息

Un Bulent, Ceyhan Dilek, Yelken Birgul

机构信息

Department of Anesthesiology and Reanimation, School of Medicine, Osmangazi University, Eskisehir, Turkey.

出版信息

J Res Med Sci. 2011 Nov;16(11):1490-4.

PMID:22973352
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3430068/
Abstract

BACKGROUND

Etomidate frequently leads to myoclonic jerks during anesthetic induction. This study aimed to detect if pretreatment with magnesium decreases myoclonus incidence.

METHODS

A hundred ASA (the American Society of Anesthesiologists) I-II patients were included and randomized into 2 groups. Three minutes before etomidate induction of anesthesia (by 0.3 mg/kg intravenous etomidate), Group M received 2.48 mmol (60 mg) intravenous magnesium sulphate and Group P received equal volume of intravenous saline. Myoclonus was evaluated as "present/absent".

RESULTS

The rate of myoclonus was significantly lower in Group M than in Group P (p < 0.01). Hemodynamic parameters revealed no significant difference between the two groups.

CONCLUSIONS

Low dose magnesium pretreatment before etomidate induction of anesthesia significantly reduces unwanted myoclonic jerks and also protects the hemodynamic stability.

摘要

背景

依托咪酯在麻醉诱导期间常导致肌阵挛。本研究旨在检测镁预处理是否能降低肌阵挛发生率。

方法

纳入100例美国麻醉医师协会（ASA）分级为I-II级的患者，并随机分为两组。在依托咪酯诱导麻醉前3分钟（静脉注射0.3mg/kg依托咪酯），M组静脉注射2.48mmol（60mg）硫酸镁，P组静脉注射等量生理盐水。评估肌阵挛为“有/无”。

结果

M组肌阵挛发生率显著低于P组（p<0.01）。两组血流动力学参数无显著差异。

结论

依托咪酯诱导麻醉前低剂量镁预处理可显著减少不必要的肌阵挛，并保护血流动力学稳定性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a2d/3430068/63ae516eb6f1/JRMS-16-1490-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a2d/3430068/7e24eb4f4db8/JRMS-16-1490-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a2d/3430068/63ae516eb6f1/JRMS-16-1490-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a2d/3430068/7e24eb4f4db8/JRMS-16-1490-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a2d/3430068/63ae516eb6f1/JRMS-16-1490-g004.jpg

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5
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