Homaee Hasan Matin, Moradi Fatah, Azarbayjani Mohammad Ali, Peeri Maghsoud
Assistant Professor, Department of Exercise Physiology, School of Physical Education and Sport Sciences, Central Tehran Branch, Islamic Azad University, Tehran, Iran.
J Res Med Sci. 2011 Dec;16(12):1612-8.
Acylated ghrelin, biologically active form of ghrelin, activates growth hormone (GH) secretagogue receptor 1a and play a role in regulating of energy balance. The purpose of this study was to survey relationships between acylated ghrelin with GH, insulin resistance, lipid profile, and cardio respiratory function in lean and obese men.
Nineteen obese men (body mass index 31.0 ± 3.5 kg/m(2), aged 27.5 ± 5.8 year) and the same number of lean men (body mass index = 18.47 ± 2.1 kg/m(2), aged 26.9 ± 5.6 year) were selected if they had no experience of regular physical activity during six month ago. After 12 hour fasting, blood samples were collected and blood parameters as well as maximal oxygen uptake (as indicator of cardiorespiratory function) was assessed.
Insulin levels and HOMA-IR (homeostasis model assessment of insulin resistance) were higher, and GH, acylated ghrelin and maximal oxygen uptake levels were lower, in obese versus lean men (p < 0.01). No significant differences were observed in systolic and diastolic blood pressure, fasting blood glucose, and lipid profiles between the two groups (p > 0.01). Plasma acylated ghrelin concentrations in obese and lean men were negatively correlated to body weight (r= -0.50, r= -0.43, respectively), body fat percent (r = -0.53, r = -0.44, respectively), body mass index (r = -0.53, r = -0.49, respectively), insulin (r = -0.42, r = -0.40, respectively) and HOMA-IR (r = -0.48, r = -0.45, respectively), and positively correlated to GH levels (r = 0.37, r = 0.31, respectively) and maximal oxygen uptake (r = 0.33, r = 0.31, respectively) (p < 0.01). No significant correlations were observed between plasma acylated ghrelin concentrations and systolic and diastolic blood pressure, fasting blood glucose, and lipid profiles in both groups (p > 0.01).
Obese and lean inactive young men had different levels of acylated ghrelin, GH, insulin, insulin resistance index, cardiorespiratory function and body fat percent. Body fat percent, insulin, and GH levels appear to be best determinant factors of acylated ghrelin levels. Also, in both obese and lean young men, higher levels of cardiovascular function were associated with higher levels of acylated ghrelin.
酰化胃饥饿素是胃饥饿素的生物活性形式，可激活生长激素（GH）促分泌素受体1a，并在调节能量平衡中发挥作用。本研究旨在调查瘦人和肥胖男性中酰化胃饥饿素与GH、胰岛素抵抗、血脂谱及心肺功能之间的关系。
选取19名肥胖男性（体重指数31.0±3.5kg/m²，年龄27.5±5.8岁）和相同数量的瘦男性（体重指数=18.47±2.1kg/m²，年龄26.9±5.6岁），前提是他们在六个月前没有规律体育活动经历。禁食12小时后，采集血样并评估血液参数以及最大摄氧量（作为心肺功能指标）。
与瘦男性相比，肥胖男性的胰岛素水平和HOMA-IR（胰岛素抵抗稳态模型评估）更高，而GH、酰化胃饥饿素和最大摄氧量水平更低（p<0.01）。两组之间的收缩压和舒张压、空腹血糖及血脂谱无显著差异（p>0.01）。肥胖和瘦男性的血浆酰化胃饥饿素浓度与体重（分别为r=-0.50，r=-0.43）、体脂百分比（分别为r=-0.53，r=-0.44）、体重指数（分别为r=-0.53，r=-0.49）、胰岛素（分别为r=-0.42，r=-0.40）和HOMA-IR（分别为r=-0.48，r=-0.45）呈负相关，与GH水平（分别为r=0.37，r=0.31）和最大摄氧量（分别为r=0.33，r=0.31）呈正相关（p<0.01）。两组中血浆酰化胃饥饿素浓度与收缩压和舒张压、空腹血糖及血脂谱之间均未观察到显著相关性（p>0.01）。
肥胖和瘦的不活跃年轻男性的酰化胃饥饿素、GH、胰岛素、胰岛素抵抗指数、心肺功能和体脂百分比水平不同。体脂百分比、胰岛素和GH水平似乎是酰化胃饥饿素水平的最佳决定因素。此外，在肥胖和瘦的年轻男性中，较高的心血管功能水平与较高的酰化胃饥饿素水平相关。
