氟烷对兔腰大肌和半腱肌去表皮肌纤维肌浆网钙释放的影响。

Effects of halothane on calcium release from sarcoplasmic reticulum of rabbit psoas and semitendinosus skinned muscle fibers.

作者信息

Carrier L, Villaz M

机构信息

Département de Recherche Fondamentale, Centre d'Etudes Nucléaires de Grenoble, France.

出版信息

Biochem Pharmacol. 1990 Jan 1;39(1):145-9. doi: 10.1016/0006-2952(90)90658-8.

DOI:10.1016/0006-2952(90)90658-8

PMID:2297353

Abstract

Calcium release from sarcoplasmic reticulum was investigated using skinned fibers isolated from rabbit semitendinosus and psoas muscles, representative of slow and fast fibers, respectively. In both types of fibers, halothane at the concentration of 0.03% (v/v) enhanced the Ca2(+)-induced calcium release. In the absence of cytoplasmic free Ca2+, halothane induced calcium release in a dose-dependent manner, with a similar sensitivity for both semitendinosus and psoas fibers. These results are discussed in connection with muscular diseases such as malignant hyperthermia in which the crisis is triggered during anesthesia by halothane.

摘要

利用分别取自兔半腱肌和腰大肌的去皮肤肌纤维（分别代表慢肌纤维和快肌纤维），研究了肌浆网的钙释放情况。在这两种类型的肌纤维中，浓度为0.03%（v/v）的氟烷增强了Ca2+诱导的钙释放。在没有细胞质游离Ca2+的情况下，氟烷以剂量依赖的方式诱导钙释放，半腱肌纤维和腰大肌纤维的敏感性相似。结合诸如恶性高热等肌肉疾病对这些结果进行了讨论，在恶性高热这种疾病中，麻醉期间氟烷会引发危机。