Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, V5Z 4H4, Canada.
G3 (Bethesda). 2012 Sep;2(9):987-1002. doi: 10.1534/g3.112.003202. Epub 2012 Sep 1.
oPOSSUM-3 is a web-accessible software system for identification of over-represented transcription factor binding sites (TFBS) and TFBS families in either DNA sequences of co-expressed genes or sequences generated from high-throughput methods, such as ChIP-Seq. Validation of the system with known sets of co-regulated genes and published ChIP-Seq data demonstrates the capacity for oPOSSUM-3 to identify mediating transcription factors (TF) for co-regulated genes or co-recovered sequences. oPOSSUM-3 is available at http://opossum.cisreg.ca.
oPOSSUM-3 是一个网络可访问的软件系统，用于识别共表达基因的 DNA 序列或高通量方法（如 ChIP-Seq）生成的序列中过度表达的转录因子结合位点 (TFBS) 和 TFBS 家族。该系统与已知的共调控基因集和已发表的 ChIP-Seq 数据的验证表明，oPOSSUM-3 有能力识别共调控基因或共同回收序列的中介转录因子 (TF)。oPOSSUM-3 可在 http://opossum.cisreg.ca 获取。
