Iqbal M, Connolly S, Langan Y, Redmond J
Department of Neurology, St James's Hospital, James's St, Dublin 8.
Ir Med J. 2012 Jun;105(6):183-4.
Lambert-Eaton myasthenic syndrome (LEMS) is a rare autoimmune disorder of neuromuscular transmission (NMJ) that shares many clinical features with myasthenia gravis (MG). We report a 73 year-old lady who presented 10 years previously with stiffness of both calves, dry mouth, fatigue, proximal weakness and areflexia in lower limbs. Neurophysiological studies were consistent with LEMS. Her work up for an underlying neoplasm was negative. She recently developed unilateral ptosis and diplopia which dramatically improved with pyridostigmine suggesting concomitant MG.
兰伯特-伊顿肌无力综合征（LEMS）是一种罕见的神经肌肉传递（NMJ）自身免疫性疾病，与重症肌无力（MG）有许多共同的临床特征。我们报告一位73岁女性，她10年前出现双侧小腿僵硬、口干、疲劳、近端肌无力和下肢腱反射消失。神经生理学研究结果与LEMS相符。她针对潜在肿瘤的检查结果为阴性。她最近出现单侧上睑下垂和复视，使用吡啶斯的明后症状显著改善，提示合并MG。
