Center for Gene Regulation in Health and Disease, Cleveland State University, 2351 Euclid Avenue, Cleveland, Ohio 44115, USA.
BMC Med. 2012 Sep 13;10:104. doi: 10.1186/1741-7015-10-104.
Influenza has a long history of causing morbidity and mortality in the human population through routine seasonal spread and global pandemics. The high mutation rate of the RNA genome of the influenza virus, combined with assortment of its multiple genomic segments, promote antigenic diversity and new subtypes, allowing the virus to evade vaccines and become resistant to antiviral drugs. There is thus a continuing need for new anti-influenza therapy using novel targets and creative strategies. In this review, we summarize prospective future therapeutic regimens based on recent molecular and genomic discoveries.
流感病毒 RNA 基因组的高突变率，加上其多个基因组片段的重组，促进了抗原多样性和新亚型的产生，使病毒能够逃避疫苗的作用并对抗病毒药物产生耐药性。因此，需要使用新的靶点和创造性策略开发新的抗流感治疗方法。在本文中，我们根据最近的分子和基因组发现，总结了有前景的未来治疗方案。
