Kodavatiganti Ravi, Campbell Fiona, Hashmi Ahmed, Gollins Simon W
North Wales Cancer Treatment Centre, Glan Clwyd Hospital, Sarn Lane, Denbighshire, LL18 5UJ, UK.
J Med Case Rep. 2012 Sep 13;6:295. doi: 10.1186/1752-1947-6-295.
Primary squamous cell carcinoma of the pancreas is a rare tumor with poor prognosis and is found in the literature only as case reports. The optimal management course remains poorly defined. We present a case of primary basaloid squamous cell carcinoma of the pancreas metastatic to the liver, which was treated with surgery and systemic chemotherapy. Our patient survived for 15 months: the longest survival reported in the literature to date.
A 70-year-old Caucasian man presented to hospital with a three-month history of weight loss, pruritus and icterus. Imaging studies confirmed the presence of an operable mass lesion in the head of the pancreas. Following a pancreaticoduodenectomy, histology results led us to make a diagnosis of squamous cell carcinoma. Postoperative restaging showed multiple metastases in the liver. He underwent palliative systemic chemotherapy with cisplatin and 5-fluorouracil achieving partial response and an excellent quality of life. He then went on to start second-line chemotherapy, but unfortunately died of sepsis soon thereafter.
This case report emphasizes that achievement of a worthwhile objective and symptomatic palliative response is possible using platinum-based chemotherapy in squamous cell carcinoma of the pancreas.
胰腺原发性鳞状细胞癌是一种预后较差的罕见肿瘤，在文献中仅作为病例报告出现。最佳治疗方案仍不明确。我们报告一例胰腺原发性基底样鳞状细胞癌转移至肝脏的病例，该病例接受了手术和全身化疗。我们的患者存活了15个月，这是迄今为止文献报道的最长生存期。
一名70岁的白人男性因体重减轻、瘙痒和黄疸3个月病史入院。影像学检查证实胰腺头部存在可手术切除的肿块病变。胰十二指肠切除术后，组织学检查结果确诊为鳞状细胞癌。术后重新分期显示肝脏有多处转移。他接受了顺铂和5-氟尿嘧啶的姑息性全身化疗，取得了部分缓解且生活质量良好。随后他开始二线化疗，但不幸的是不久后死于败血症。
本病例报告强调，在胰腺鳞状细胞癌中使用铂类化疗有可能实现有价值的目标并获得症状性姑息反应。
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