Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore, MD3, 16 Medical Drive, Singapore, 117597.
Mini Rev Med Chem. 2013 Jun;13(7):1056-72. doi: 10.2174/1389557511313070009.
Malaria is an infectious disease causing almost one million deaths each year. There is an urgent need for discovery of new antimalarial compounds. Natural products have been the single most productive source of leads for the development of drugs, because of their great variety of chemical structures. This review covers studies on antimalarial natural products isolated from plants, published from January 2010 until April 2012. A total of 171 structures comprising alkaloids, terpenoids, phenolics and other metabolites are listed in this review, including information on their antiplasmodial and cytotoxic activity.
疟疾是一种传染病，每年导致近 100 万人死亡。迫切需要发现新的抗疟化合物。由于其化学结构的多样性，天然产物一直是开发药物的最具成效的先导化合物来源。本综述涵盖了 2010 年 1 月至 2012 年 4 月期间从植物中分离出的抗疟天然产物的研究。本文共列出了 171 种结构的生物碱、萜类、酚类和其他代谢产物，包括它们的抗疟原虫和细胞毒性活性的信息。
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