睡眠剥夺会改变杏仁核中磷酸化 CREB 的水平：与恐惧条件反射任务中的表现的关系。

Sleep deprivation alters phosphorylated CREB levels in the amygdala: relationship with performance in a fear conditioning task.

机构信息

Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

出版信息

Behav Brain Res. 2013 Jan 1;236(1):221-224. doi: 10.1016/j.bbr.2012.08.043. Epub 2012 Sep 4.

DOI:10.1016/j.bbr.2012.08.043

Abstract

We investigated the relationship between deficits in fear memory induced by sleep deprivation and pCREB expression in the basal and central nuclei of the amygdala. Sleep deprivation reduced pCREB expression in the central nucleus compared to control or sleep recovered groups, and in the basal nucleus only compared to sleep recovered group. Moreover, 24h of sleep recovery prior to training prevented changes in both pCREB expression and performance.

摘要

我们研究了睡眠剥夺引起的恐惧记忆缺陷与杏仁核基底核和中央核中 pCREB 表达之间的关系。与对照组或睡眠恢复组相比，睡眠剥夺降低了中央核中 pCREB 的表达，与睡眠恢复组相比，仅降低了基底核中 pCREB 的表达。此外，在训练前进行 24 小时的睡眠恢复可防止 pCREB 表达和表现的变化。