School of Health and Social Care, Teesside University, Middlesbrough TS1 3BA, UK.
Br J Nutr. 2013 May 28;109(10):1903-9. doi: 10.1017/S0007114512003583. Epub 2012 Sep 14.
F is an important trace element for bones and teeth. The protective effect of F against dental caries is well established. Urine is the prime vehicle for the excretion of F from the body; however, the relationship between F intake and excretion is complex: the derived fractional urinary F excretion (FUFE) aids understanding of this in different age groups. The present study aimed to investigate the relationships between (1) total daily F intake (TDFI) and daily urinary F excretion (DUFE), and (2) TDFI and FUFE in 6-7-year-olds, recruited in low-F and naturally fluoridated (natural-F) areas in north-east England. TDFI from diet and toothbrushing and DUFE were assessed through F analysis of duplicate dietary plate, toothbrushing expectorate and urine samples using a F-ion-selective electrode. FUFE was calculated as the ratio between DUFE and TDFI. Pearson's correlation and regression analysis were used to investigate the relationship between TDFI and FUFE. A group of thirty-three children completed the study; twenty-one receiving low-F water (0·30 mg F/l) and twelve receiving natural-F water (1·06 mg F/l) at school. The mean TDFI was 0·076 (SD 0·038) and 0·038 (SD 0·027) mg/kg per d for the natural-F and low-F groups, respectively. The mean DUFE was 0·017 (SD 0·007) and 0·012 (SD 0·006) mg/kg per d for the natural-F and low-F groups, respectively. FUFE was lower in the natural-F group (30 %) compared with the low-F group (40 %). Pearson's correlation coefficient for (1) TDFI and DUFE was +0·22 (P= 0·22) and for (2) TDFI and FUFE was − 0·63 (P< 0·001). In conclusion, there was no correlation between TDFI and DUFE. However, there was a statistically significant negative correlation between FUFE and TDFI.
氟是骨骼和牙齿的重要微量元素。氟对龋齿有很好的保护作用。尿液是氟从体内排泄的主要载体；然而，氟的摄入和排泄之间的关系很复杂：衍生的尿氟排泄分数（FUFE）有助于理解不同年龄组的情况。本研究旨在调查（1）总日氟摄入量（TDFI）和日尿氟排泄量（DUFE），以及（2）在英格兰东北部低氟和自然氟地区招募的 6-7 岁儿童的 TDFI 和 FUFE 之间的关系。通过氟离子选择性电极分析饮食板、刷牙吐口水和尿液样本中的氟来评估饮食和刷牙的 TDFI 和 DUFE。FUFE 计算为 DUFE 与 TDFI 的比值。采用皮尔逊相关和回归分析来研究 TDFI 与 FUFE 之间的关系。有 33 名儿童完成了研究；21 名在学校饮用低氟水（0.30mgF/l），12 名饮用自然氟水（1.06mgF/l）。自然氟组和低氟组的 TDFI 平均值分别为 0.076（SD0.038）和 0.038（SD0.027）mg/kg/d。自然氟组和低氟组的 DUFE 平均值分别为 0.017（SD0.007）和 0.012（SD0.006）mg/kg/d。自然氟组的 FUFE （30%）明显低于低氟组（40%）。（1）TDFI 与 DUFE 之间的皮尔逊相关系数为+0.22（P=0.22），（2）TDFI 与 FUFE 之间的皮尔逊相关系数为-0.63（P<0.001）。总之，TDFI 与 DUFE 之间没有相关性。然而，FUFE 与 TDFI 之间存在统计学上显著的负相关。
