Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, North Carolina, USA.
Prog Mol Biol Transl Sci. 2012;112:307-22. doi: 10.1016/B978-0-12-415813-9.00011-8.
Dramatic changes are beginning to take place in risk assessment, changes that will involve rapid, high-throughput assays capable of analyzing large numbers of samples in a short time. These new systems will incorporate many of the aspects of cellular and molecular biology, including human and human-derived cell lines, toxicogenomics, proteomics, and metabolomics. The large amount of data generated will require a systems biology approach if it is to be reduced to generalizations of value in risk management. The current chapter briefly describes the emerging systems and their component parts.
风险评估正开始发生戏剧性的变化，这些变化将涉及能够在短时间内分析大量样本的快速、高通量检测。这些新系统将包含许多细胞和分子生物学的方面，包括人类和人源细胞系、毒理基因组学、蛋白质组学和代谢组学。如果要将大量生成的数据简化为风险管理中有价值的概括，就需要采用系统生物学方法。本章简要描述了新兴系统及其组成部分。
