Bradford R, Darling J L, Thomas D G
Gough-Cooper Department of Neurological Surgery, Institute of Neurology, London, UK.
Br J Cancer. 1990 Jan;61(1):46-50. doi: 10.1038/bjc.1990.10.
Using a cell line derived from the VM spontaneous murine astrocytoma, a reliable in vitro-in vivo model of human malignant glioma has been developed. In this paper we examine the effects of cytotoxic drugs with known activity against other animal brain tumour models and human disease on the in vivo VM model. The drugs BCNU, CCNU and vincristine produced significant volume reduction in tumours growing at a subcutaneous location in syngeneic animals. Procarbazine was ineffective. Similarly, BCNU, CCNU and vincristine produced small but statistically significant increases in survival of VM mice bearing the intracerebral tumour, but procarbazine was again ineffective. The modest, but significant, response of the VM model to the nitrosoureas mimics the human situation more closely than previously described animal models.
利用源自VM自发性小鼠星形细胞瘤的细胞系，已开发出一种可靠的人恶性胶质瘤体外-体内模型。在本文中，我们研究了对其他动物脑肿瘤模型和人类疾病具有已知活性的细胞毒性药物对体内VM模型的影响。药物卡莫司汀、洛莫司汀和长春新碱使同基因动物皮下生长的肿瘤体积显著减小。丙卡巴肼无效。同样，卡莫司汀、洛莫司汀和长春新碱使患有脑内肿瘤的VM小鼠的生存期有小幅但具有统计学意义的延长，但丙卡巴肼再次无效。VM模型对亚硝基脲类药物的适度但显著的反应比先前描述的动物模型更接近人类情况。
