Department of Internal Medicine, Connective Tissue Diseases and Geriatrics, Medical University of Gdańsk, Poland.
Cell Immunol. 2012 Jul-Aug;278(1-2):143-51. doi: 10.1016/j.cellimm.2012.08.001. Epub 2012 Aug 23.
The role of CD28- T cell subpopulations in primary Sjögren's syndrome (pSS) has become controversial. Changes in the number of CD28- T cells have been demonstrated in autoimmune diseases in co-existence with Sjögren's syndrome. The study aimed to indicate differences in the number of CD4+CD28- and CD8+CD28- T cells in patients with sicca syndrome and suspected pSS. Thirty patients with sicca syndrome at baseline were studied and followed up for 5 months. After final diagnosis, comparison was made of the previously recorded lymphocyte subpopulations in patients with pSS and those in other defined subgroups. Notably high percentages of CD8+CD28- T cells were indicated in pSS patients, which correlated with the severity of the sicca symptoms and cutaneous and muscular systemic disease activity. Changes in CD8+CD28- T cell percentages may thus assist in the early differential diagnosis of pSS patients from those with similar clinical symptoms.
CD28- T 细胞亚群在原发性干燥综合征（pSS）中的作用一直存在争议。在合并干燥综合征的自身免疫性疾病中，已经证明 CD28- T 细胞数量发生了变化。本研究旨在指出干燥综合征患者和疑似 pSS 患者中 CD4+CD28- 和 CD8+CD28- T 细胞数量的差异。在基线时研究了 30 例干燥综合征患者，并随访了 5 个月。最终诊断后，比较了 pSS 患者和其他明确亚组患者之前记录的淋巴细胞亚群。pSS 患者的 CD8+CD28- T 细胞百分比显著升高，与干燥症状的严重程度以及皮肤和肌肉全身性疾病活动相关。因此，CD8+CD28- T 细胞百分比的变化可能有助于早期对 pSS 患者与具有相似临床症状的患者进行鉴别诊断。
