Department of Epidemiology and Preventive Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan.
Lung Cancer. 2012 Nov;78(2):144-7. doi: 10.1016/j.lungcan.2012.08.011. Epub 2012 Sep 10.
Our previous study reported a frequent detection of human papillomavirus (HPV) genome in primary lung adenocarcinomas of the recurrent patients who were responsive to epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor, suggesting that HPV presence in lung cancer may be related to a genetic background related to EGFR mutations. The present study examined the association between the HPV presence and mutations in exons 19 and 21 of EGFR gene in Japanese lung cancer patients. Thirteen (31%) out of 42 cases had EGFR mutations. Although these mutations were tended to be observed in females, non-smokers, or adenocarcinomas, there was no statistically significant associations. HPV DNA was found in 7/42 (17%) lung tumors. The frequency of HPV presence did not differ in histological types. The presence of HPV DNA was significantly related to EGFR mutations (P=0.021), especially in adenocarcinomas of the lung (P=0.014). HPV-positive lung tumors accounted for 38% and 7% of those with and without EGFR mutations, respectively. Our results suggest that EGFR mutations are associated with HPV presence in Japanese patients with lung cancer.
我们之前的研究报告称，在对表皮生长因子受体 (EGFR)-酪氨酸激酶抑制剂有反应的复发性原发性肺腺癌患者中经常检测到人类乳头瘤病毒 (HPV) 基因组，这表明肺癌中 HPV 的存在可能与与 EGFR 突变相关的遗传背景有关。本研究在日本肺癌患者中检查了 HPV 存在与 EGFR 基因外显子 19 和 21 突变之间的关联。在 42 例中有 13 例（31%）存在 EGFR 突变。尽管这些突变更倾向于在女性、不吸烟者或腺癌中观察到，但没有统计学上的显著关联。在 7/42（17%）的肺肿瘤中发现了 HPV DNA。HPV 存在的频率在组织学类型上没有差异。HPV DNA 的存在与 EGFR 突变显著相关（P=0.021），尤其是在肺腺癌中（P=0.014）。HPV 阳性肺肿瘤分别占有和无 EGFR 突变的肺肿瘤的 38%和 7%。我们的研究结果表明，在日本肺癌患者中，EGFR 突变与 HPV 的存在相关。
