Department of Chemistry, Guangxi University, Nanning, 530004, PR China.
Fitoterapia. 2012 Dec;83(8):1558-61. doi: 10.1016/j.fitote.2012.09.001. Epub 2012 Sep 11.
Geniposide was prepared on a large-scale using a selective two-phase liquid-liquid extraction. The aqueous residue from the fruit of Gardenia jasminoides Ellis was treated with sodium carbonate and extracted with n-butanol several times. The n-butanol extracts were treated with activated granular charcoal to remove pigments and were then concentrated to produce a residue with a high solid content. The residue was crystallized to obtain geniposide with 98% purity. For large-scale synthesis, the residue (solid content 45%, geniposide 5.5%) was extracted to generate 70g of geniposide with 98% purity and 84.8% recovery using 1500g residue.
栀子苷采用选择性双相液-液萃取法进行大规模制备。先用碳酸钠处理栀子（Gardenia jasminoides Ellis）果实的水提残渣，然后用正丁醇多次萃取。正丁醇提取物用活性颗粒活性炭处理以去除色素，然后浓缩得到高固含量的残渣。残渣结晶得到栀子苷，纯度为 98%。对于大规模合成，使用 1500g 残渣提取固含量为 45%、栀子苷含量为 5.5%的残渣，生成 70g 纯度为 98%、收率为 84.8%的栀子苷。
