Stein Y, Dabach Y, Hollander G, Stein O
Department of Medicine B, Hadassah University Hospital, Jerusalem, Israel.
Biochim Biophys Acta. 1990 Jan 16;1042(1):138-41. doi: 10.1016/0005-2760(90)90068-9.
We investigated the presence of cholesteryl ester transfer activity (CETA) in plasma of hamsters kept on various dietary regimens. In hamsters kept on a regular diet, CETA activity was about 5 units/4 mg protein of d greater than 1.21 g/ml fraction of plasma, as compared to about 35 units present in human d greater than 1.21 g/ml fraction. Addition of 15% margarine or butter alone or together with 2% cholesterol resulted in a 2-3-fold increase in plasma CETA. The increase in plasma CETA was correlated with plasma cholesterol levels (r = 0.78; P less than 0.001) and plasma triacylglycerol levels (r = 0.56, P less than 0.001). Hamsters consuming the cholesterol + butter-supplemented diets had the highest plasma CETA, cholesterol and triacylglycerol levels, while CETA in plasma of rats and mice remained nondetectable even after 4 weeks on the diet. The causal relation between hypercholesterolemia, hypertriglyceridemia and evaluation in CETA in hamsters remains to be elucidated.
我们研究了处于不同饮食方案下的仓鼠血浆中胆固醇酯转移活性（CETA）的存在情况。在正常饮食的仓鼠中，与人类密度大于1.21 g/ml的血浆组分中约35个单位相比，密度大于1.21 g/ml的血浆组分中CETA活性约为5个单位/4 mg蛋白质。单独添加15%人造黄油或黄油，或同时添加2%胆固醇，会使血浆CETA增加2至3倍。血浆CETA的增加与血浆胆固醇水平（r = 0.78；P < 0.001）和血浆三酰甘油水平（r = 0.56，P < 0.001）相关。食用补充了胆固醇+黄油饮食的仓鼠血浆CETA、胆固醇和三酰甘油水平最高，而大鼠和小鼠即使在饮食4周后血浆中的CETA仍无法检测到。仓鼠中高胆固醇血症、高甘油三酯血症与CETA升高之间的因果关系仍有待阐明。
